The neurobiology of huntington's disease: applications to drug discovery

Highlighting advances in the discovery and development of new drug therapiesfor neurodegenerative disorders, "Neurobiology of Huntington's Disease" focuses on the many aspects of the research on drugs to treat Huntington's disease.It discusses genetics, genomics, and proteomics, and the latest in high-throughput and high-content screening. The authors provide introductory background as well as highly sophisticated information on current and future directions of research. Exploring the interplay between academic and industrial research, the investment community, and non-profit contributors, the book also examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage. INDICE: Huntington's Disease: Clinical Features and Routes to Therapy, Henry L. Paulson and Roger L. Albin Huntington's Disease Pathogenesis: Mechanismsand Pathways, Albert R. La Spada, Patrick Weydt, and Victor V. Pineda ProteinInteractions and Target Discovery in Huntington's Disease, John P. Miller andRobert E. Hughes Target Validation for Huntington's Disease, Seung P. Kwak, James K. T. Wang, and David S. Howland High-Throughput and High-Content Screening for Huntington's Disease Therapeutics, Hemant Varma, Donald C. Lo, and Brent R. Stockwell Value of Invertebrate Genetics and Biology to Develop Neuroprotective and Preventive Medicine in Huntington's Disease, Christian Neri Mouse Models for Validating Preclinical Candidates for Huntington's Disease, X. William Yang and Michelle Gray Pharmaceutical Development for Huntington's Disease,Richard J. Morse, Janet M. Leeds, Douglas Macdonald, Larry Park, Leticia Toledo-Sherman, and Robert Pacifici RNA- and DNA-Based Therapies for Huntington's Disease, Meghan Sass and Neil Aronin Recombinant Intrabodies as Molecular Tools and Potential Therapeutics for Huntington's Disease, Ali Khoshnan, Amber Southwell, Charles W. Bugg, Jan C. Ko, and Paul H. Patterson Biomarkers to Enablethe Development of Neuroprotective Therapies for Huntington's Disease, StevenM. Hersch and H. Diana Rosas Huntington's Disease, E. Ray Dorsey and Ira Shoulson

• ISBN: 978-0-8493-9000-5
• Editorial: CRC Press
• Encuadernacion: Tela
• Páginas: 338
• Fecha Publicación: 01/01/2010
• Nº Volúmenes: 1
• Idioma: Inglés