Molecular, clinical and environmental toxicology v. 1 Molecular toxicology

Molecular Toxicology is the first volume of a three-volume set on molecular, clinical and environmental toxicology that offers a comprehensive and in-depthresponse to the increasing importance and abundance of chemicals of daily life. By providing intriguing insights far down to the molecular level, this three-volume work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, publich health or engineering who are demanding reliable information on toxic or potentially harmful agents and their effects on the human body. Presents milestones and recent achievements of toxicology Explains mechanisms of toxicity at the molecular level Discusses toxicogenomics and individual variability INDICE: Historical milestones and discoveries that shaped the Toxicology Sciences.- hysiologically-based toxicokinetic models and their application in human exposure and internal dose assessment.- The role of biotransformation andbioactivation in toxicity.- Genotoxicity: Damage to DNA and its consequences.- Role of DNA repair in the protection against genotoxic stress.- On the impact of the molecule structure in chemical carcinogenesis.- Chemical induced alterations in p53 signaling.- Molecular pathways involved in cell death after chemically induced DNA damage.- The Ah receptor at the crossroads of multiple signaling pathways.- Mapping the epigenome – impact for toxicology.- Receptors mediating toxicity and their involvement in endocrine disruption.- Toxicogenomics: Transcription profiling for toxicology assessment.- The role of toxicoproteomics in assessing organ specific toxicity.- High throughput screening for analysis of in vitro toxicity.

• ISBN: 978-3-7643-8335-0
• Editorial: Birkhaüser
• Encuadernacion: Cartoné
• Páginas: 500
• Fecha Publicación: 01/12/2008
• Nº Volúmenes: 1
• Idioma: Inglés