Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters: Concepts, Methods, and Translational Sciences

Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, provides an overview of the last decade's numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. Due to these advances, as well as new modelling and simulation approaches that better predict human dosage, clearance and pharmacokinetics in the last decade have shaped the fields of drug metabolism and translational sciences. This completely updated second edition features all-new chapters written by experts with a wide range of practical experience from the pharmaceutical industry, with emphasis placed on techniques and applications. It goes beyond LC-MS and covers several other analytical techniques not covered in the first edition. The book also includes chapters on how to utilize modern instrumentation for current drug metabolism problems. Gives readers an overview of state-of-the-art techniques for identifying and quantifying drugs and metabolites, such as Super Fluid Chromatography and the use of stable isotopes in drug metabolismFocuses on drug metabolism enzymes, transporters and drug-drug interaction, as well as strategies for evaluating drug metabolism and safetyIncludes a section on translational sciences including modelling and simulations INDICE: Part I: Techniques for Identifying and Quantifying Drugs and Metabolites 1. Strategies for increasing throughput for PK samples in a drug discovery environment 2. Metabolite Identification by LC-MS 3. GCMS 4. Metabolite Generation and Metabolite Characterization by NMR 5. Antibody-drug-conjugate (ADC) Bioanalysis 6. Application of SFC for bioanalysis 7. AMS, ABA, microtracer studies Part II: Drug Metabolism Enzymes, Transporters and Drug-Drug Interaction 8. Drug Metabolizing Enzymes 9. Transporters 10. Drug-Drug Interaction 11. Clearance Mechanism and Reaction Phenotyping 12. Transporter mediated DDI 13. Endogenous biomarkers- new paradigm in DDI studies Part III: Strategy Related to Drug Metabolism and Safety 14. Metabolites in safety testing (MIST) 15. DILI, role of transporters and reactive metabolites 16. The use of stable isotope in drug metabolism studies 17. Strategy for chiral inversion Part IV: Translational Sciences 18. Chimeric and genetically engineered animals to human translations 19. Clearance IVIVE 20. Modelling: PBPK, PKPD

• ISBN: 978-0-12-820018-6
• Editorial: Elsevier Science
• Encuadernacion: Rústica
• Fecha Publicación: 01/07/2020
• Nº Volúmenes: 1
• Idioma: Inglés