Updated and revised, this fourth edition of a perennial bestseller provides current and comprehensive information on all aspects of drug design and discovery. It describes specific strategies employed by medicinal chemists to advancepromising molecules into clinical use for the alleviation of disease. The fourth edition includes new chapters on products of natural origin as leads in drug design, chemical biology, ADME-tox properties, bioinformatics and chemoinformatics in drug research, combinatorial chemistry, parallel synthesis, high-throughput screening, imaging in drug design, computer modeling techniques, genetechnology, and target validation. INDICE: Introduction to Drug Design and Discovery, P. Krogsgaard-Larsen and L. Bunch Molecular Recognition in Ligand--Protein Binding, T. Liljefors Biostructure-Based Drug Design, F. S. Jorgensen and J. S. Kastrup Ligand-Based Drug Design, I. Pettersson, T. Balle, and T. Liljefors Chemical Biology, K. Stromgaard Stereochemistry in Drug Design, M. B. Mayo-Martin and D. E. Jane Natural Products in Drug Discovery, G. T. Carter Imaging in Drug Discovery and Development, M. Rudin and T. Mueggler Peptides and Peptidomimetics, M. Cai, V. V. Kulkarni, and V. J. Hruby Prodrugs: Design and Development, A. Buur and N. Mork Metals in Medicine: Inorganic Medicinal Chemistry, H. R. Hansen and O. Farver Enzyme Inhibitors: Biostructure-Based and Mechanism-Based Designs, R. A. Copeland, R. R. Gontarek, and L. Luo Receptors: Structure, Function, and Pharmacology, H. Brauner-Osborne Ion Channels: Structure and Function, S.-P. Olesen and D. B. Timmermann Neurotransmitter Transporters: Structure and Function, C. J. Loland and U. Gether GABA and Glutamic Acid Receptor Ligands, B. Frolund andU. Madsen Acetylcholine, A. A. Jensen and P. Krogsgaard-Larsen Histamine Receptors, I. de Esch, H. Timmerman, and R. Leurs Dopamine and Serotonin, B. Bang-Andersen and K. P. Bogeso Opioid and Cannabinoid Receptors, R. P. Clausen and H. S. Hansen Hypnotics, B. Ebert and K. A. Wafford Neglected Diseases, S. B. Christensen Immunomodulating Agents, U. G. Sidelmann Anticancer Agents, F. Bjorkling and L. H. Jensen Antiviral Drugs, E. De Clercq Antibiotics, P. HerdewijnIndex
- ISBN: 978-1-4200-6322-6
- Editorial: CRC Press
- Encuadernacion: Desconocida
- Páginas: 400
- Fecha Publicación: 01/03/2009
- Nº Volúmenes: 1
- Idioma: Inglés