Cancer is a primary cause of human mortality worldwide. Despite decades of basic and clinical research, the outcome for most cancer patients is still dismal. Some stumbling blocks to developing effective therapy include the heterogeneity of cancer tissues, the lack of knowledge about the critical molecular mechanisms in cancer tissues (which are typically aberrant compared with mechanisms in normal tissue), and the lack of good mechanism-based therapeutic approaches. The recent findings that most cancers contain a small fraction of self-renewing, differentiation-blocked stem cell-like cells (cancer stem cells) and that it is these cells—and not the major bulk of the tissue—that are the root cause for cancer initiation and metastasis have also highlighted the need to change our approach to cancer therapy. Will provide timely, cutting-edge information about cancer stem cells from the perspectives of both the basic and clinical sciences INDICE: Introduction.- Stem Cells and Cancer: An Introduction.- Molecular Regulation of the State of Embryonic Stem Cells.- MicroRNAs in Stem Cells and Cancer Stem Cells.- Cancer Stem Cell and Metastasis: Emerging Themes and Therapeutic Implications.- Stem Cells in Leukemia and Other Hematological Malignanices.- Prostate Cancer Stem Cells.- Breast Cancer Stem Cells.- Stem Cells and Lung Cancer.- Cancer Stem Cells in Colorectal Cancer.- Cancer stem cells and skin cancer.- Lineage Relationships Connecting Germinal Regions to Brain Tumors.
- ISBN: 978-0-387-89610-6
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 260
- Fecha Publicación: 01/05/2009
- Nº Volúmenes: 1
- Idioma: Inglés