Genetics, Neurology, Behavior, and Diet in Dementia: The Neuroscience of Dementia, Volume 2

The Neuroscience of Dementia: Genetics, Neurology, Behavior, and Diet brings together different fields of dementia into a single coherent book. It covers a wide range of subjects including the different types of dementia (Alzheimer's disease, Lewy body dementia, mixed dementia, vascular dementia), physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, molecular biology, and many other focused areas. This foundational, comprehensive book brings together the current status of understanding on all dementias and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. The most comprehensive coverage of the broad range of topics related to DementiaServes as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunctionContains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understandingUniquely sections on specific subareas, intellectual components and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendationsPreclinical and clinical studies will help researchers map out key areas for research and further clinical recommendationsA one-stop source for everything you need to know about Dementia INDICE: Section 1 Genetic Aspects of Dementia 1. GWAS and microglial genes in dementia 2. CD36 gene polymorphism and Alzheimer's disease 3. Klotho gene polymorphism and dementia 4. Apolipoprotein E Isoforms and amyloid-beta-Induced Inflammation 5. A1 purinergic receptor gene expression in dementia 6. MicroRNAs in dementia Section 2 Neurological and Imaging Features 7. Amyloid imaging 8. Senile plaques in Alzheimer's disease - from molecules to cells 9. Tau and amyloid-beta in different stages of Alzheimer's disease 10. Neuroinflammation in dementia 11. Neurofibrillary tangles in dementia 12. Neuronal toll-like receptor 4 and Alzheimer disease 13. Neuronal susceptibility to hypoxia in Alzheimer disease 14. Brain region volumes in neurodegenerative dementia 15. Brain receptors in Alzheimer's disease 16. Glial cells in neurodegenerative dementia 17. Sphingolipids of neurones in Alzheimer's disease 18. Amyloid beta in Alzheimer 19. The mitochondria in dementia 20. Synaptosomal bioenergetics in Alzheimer's disease 21. Ribonucleoprotein (RNP) granules in dementia Section 3 Behavior and Psychopathological Effects 22. Memory impairment in dementia 23. Cognitive Impairments in dementia 24. Sleep in Alzheimer's disease 26. Connecting hearing loss and Quality of Life in dementia 27. Agitation in dementia 28. Aggression in dementia 29. Delusions in dementia 30. Anxiety in dementia 31. Depression in Alzheimer's disease 32. Hallucinations in dementia 33. Psychotic symptoms in dementias Section 4 Diet and Nutrition 34. Vitamin E in dementia 35. Body mass index (BMI and mortality in dementia 36. Omega-3 fatty acids in dementia 37. Mediterranean diet and dementia Section 5 Molecular and Cellular Effects of Dementia 38. Stem cells and dementia 39. TRPM2 and TRPV1 Channels in dementia 40. Synuclein in dementia 41. Molecular aspects of neuroinflammation in dementia 42. Molecular aspects of metallothionein-1 in dememtias Section 6 Models and Modelling in Dementia 43. Animal models of dementia and their applications 44. Alzheimer's model 5xFAD mice as a model and applications to dementia 45. Use of 192 IgG-saporin as a model of dementia and its application 46. Abeta1-42 oligomer animal model of dementia 47. Clinical model of dementia support

• ISBN: 978-0-12-815868-5
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 745
• Fecha Publicación: 01/08/2020
• Nº Volúmenes: 1
• Idioma: Inglés