Oxidative Stress and Dietary Antioxidants in Neurological Diseases

Very often oxidative stress is a feature of neurological disease and associated conditions which either centres on or around molecular and cellular processes. Oxidative stress can also arise due to nutritional imbalance during a spectrum of time frames, before the onset of disease or during its development. Oxidative Stress and Dietary Antioxidants in Neurological Diseases aims to provide a comprehensive overview of oxidative stress in neurological diseases and associated conditions or scenarios including aspects of behaviour, and the potentially therapeutic usage of natural antioxidants in the diet or food matrix. However, the processes within the science of oxidative stress are not described in isolation but in concert with other processes such as apoptosis, cell signalling, receptor mediated responses and so on. This approach recognizes that diseases are often multifactorial and oxidative stress is a single component of this. The book begins with an overview of the basic processes of oxidative stress from molecular biology to whole organs in relation to basic concepts and cellular defense systems, across a broad range of neurological diseases. The next section discusses antioxidants in foods including plants and components of the diet, examining the underlying mechanisms associated with therapeutic potential and clinical application. Although some of this section is exploratory or preclinical, nonetheless it can provide the framework for further in-depth analysis or studies, via well designed clinical trials or via the analysis of pathways, mechanisms and components in order to devise new therapeutic strategies. Overview of oxidative stress from molecular biology to whole organsDiscusses the potentially therapeutic usage of natural antioxidants in the patient dietProvides the framework for further in-depth analysis or studies for potential treatment INDICE: I: Oxidative Stress and Neurological Diseases 1. Depression and reactive oxygen species 2. Blood-brain barrier and reactive oxygen species 3. Neuroinflammatory processes and oxidative stress 4. Age, neuroinflammation and oxidative stress 5. Oxidative stress in human neuneuroblastoma 6. Oxidative stress in epileptogenesis: Febrile seizures, chemoconvulsant pilocarpine and electrical stimulation. 7. Astroglial DJ-1, neuroprotection via its antioxidant effects 8. Oxidative stress markers in seizures and epilepsy: methods and applications to models II: Antioxidants and Neurological Diseases 9. Dietary antioxidants and the blood-brain barrier 10. Antioxidant and neuroprotective properties of Mediterranean oils: argan oil, olive oil and milk thistle seed oil 11. Aromatic plants: a source of compounds with antioxidant and neuroprotective effects 12. The elderly, use of antioxidants and memory 13. Aspidosperma pyrifolium Mart. antioxidants features and neuronal tissues 14. Berberine neuroprotection and antioxidant activity 15. Carnosic acid and carnosol: Neuroprotection and the mitochondria 16. Coconut oil and antioxidative neuroprotection 17. Antioxidant effects of Curcuma longa and its active constituent, curcumin, for the therapy of neurological disorders 18. Gingko biloba, memory and antioxidant profiles 19. Morinda citrifolia Linn. (noni) fruit, antioxidant effects and neuroprotection 20. Naringenin and naringin in neuroprotection and oxidative stress 21. Nigella sativa and neurological disorders: role of antioxidant activities 22. Antioxidant nutritionals, epigenetic and brain aging 23. The role of saffron and its main components on oxidative stress in neurological diseases: A review 24. Sulforaphane and its modulation of brain redox status: the mitochondria as a target 25. Resources in Pathology and oxidative stress

• ISBN: 978-0-12-817780-8
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 500
• Fecha Publicación: 01/08/2020
• Nº Volúmenes: 1
• Idioma: Inglés