Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging is a comprehensive reference on the diagnosis and management of neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. It also examines pharmacological and non-pharmacological interventions of age-related conditions that affect the brain including Alzheimer's, stroke, and multiple sclerosis. Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurological aging. It also examines the use of animal modelling of aging and neurological disease. Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging: Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of aging Features sections on diagnosis and biomarkers of neurological aging, Alzheimer's, and stroke Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Focuses on neurological diseases and conditions linked to aging, environmental factors, and clinical recommendations Includes more than 500 illustrations and tables Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet: Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of aging Features sections on the genetics influencing aging and diseases of aging Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Focuses on neurological diseases and conditions linked to aging, environmental factors, and clinical recommendations Includes more than 500 illustrations and tables INDICE: Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging I. Introductory chapters: Setting the scene for the neuroscience of aging 1. The concept of productive aging; 2. Quality of life in the over 80s; 3. Successful aging and diet; 4. The impact of positive social relations on the quality of life of older people. An alternative to medicalization from an integral perspective; 5. The brain in life span: use of phase fMagnetic Resonance Imaging (MRI); 6. Neuronal structure in aging: Cytoskeleton in health and disease; 7. Sporadic Alzheimer's Triad: Age, Sex, and ApoE; 8. How polymorphisms impact: BDNF polymorphism, inhibitory performance and the elderly; 9. Menopause as an aging process and alcohol misuse; 10. Brain banking and aging II. Impairments and Diseases 11. Dementia or no dementia in the very elderly. Why?; 12. Neuropsychology, Social Cognition and Loss of Insight in Frontotemporal Dementia; 13. Neuroinflammation in the elderly; 14. Cortical microinfarcts and the aging brain; 15. Vascular brain injury and neurodegeneration in elderly racial and ethnic minority populations; 16. Hearing loss amongst the elderly; 17. Aging Auditory Cortex: The Impact of Reduced Inhibition on Function; 18. Aging and vestibular disorders; 19. Brain aging in HIV and antiretrovirals; 20. Antioxidants, Methylmercury, and Aging; 21. Aging and the effects of ethanol on the brain: Comparing the effects of different aging III. Biomarkers And Diagnosis 22. Aging brain: Radiological biomarkers; 23. Plasma ADAM10 as a biomarker of mental impairment in the elderly; 24. Circulating microRNAs as biomarkers of healthy elderly; 25. DHEA as a biomarker of aging in humans and nonhuman primates: Synthesis, neuroprotection and cognitive function; 26. Evaluation of subjective memory abilities in elderly people; 27. The Functional Activities Questionnaire: Applications to aging; 28. Autobiographical memory as a diagnostic tool in aging; 29. Assessment tools for subjective memory abilities in elderly people; 30. Knowledge of Memory Aging IV. Management and Treatments 31. Pharmacological use of transient receptor potential (TRP) ion channel antagonists in neurological disease: effects on swallowing and implications for nutrition; 32. Aripiprazole: features and use in the aged; 33. Cognition-Enhancing Drugs and Applications to Aging; 34. Creatine supplementation and impact on the aging brain; 35. Photobiomodulation as a brain-boosting strategy in aging; 36. Innovation in deep brain stimulation in aging: a focus on Parkinson Disease; 37. Exergames: what they are and how they can be used to improve cognition in aging; 38. Linking cognitive decline and ballroom dance as a therapeutic intervention in the elderly; 39. Active experiencing training in the elderly; 40. Psychiatric self-management, smartphone apps and older adults; 41. Psychosocial Interventions for Suicide Prevention in the Elderly: Advances and Future Directions V. Models And Modelling 42. D-galactose-induced aging and brain mitochondria; 43. Drosophila as a model organism in ageing research; 44. The Zebrafish (Danio rerio) and its uses for understanding the neuroscience of aging: applications and observation; 45. Murine models of primary Tauopathy as a model of aging; 46. Modelling nutrition and brain aging in rodents; 47. Modelling primates and neurological aging: a focus on Alzheimer's disease; 48. Linking aging and animal models to neurodegeneration: the Striatum, Substantia Nigra and Parkinson's Disease; 49. Behavioral evaluation of aging VI. Resources 50. Research and recommended resources in the neuroscience of aging Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, And Diet I. Genetics, Molecular and Cellular Biology 1. Genetics of frontotemporal dementia; 2. Aging, brain-derived neurotrophic factor (BDNF) and its polymorphism; 3. Aging, demented patients, and polymorphisms in cytokine genes; 4. RNA fragments and brain aging; 5. Centrosome functions and remodeling during neuronal development and centrosome abnormalities in neuronal disorders, disease, and in aging; 6. Brain aging and microarray analysis; 7. Human nuclear tau and aging; 8. Lipoxidation: features, neurological tissues and aging; 9. Aging and brain amino acids; 10. How 3',5'-cyclic nucleotide phosphodiesterases change in the brain with normal aging and dementia; 11. The prohibitin complex in aging and neurodegeneration; 12. Synaptic ATPase and energy metabolism in the nervous system: roles and changes in the aging process II. Neurological and Imaging Features 13. Microstructural Imaging of the Human Brain with Normal and Abnormal Aging using Diffusion Magnetic Resonance Imaging; 14. Imaging the brain and its vascular in aging: applications of optical coherence tomography angiography; 15. Potential involvement of perineuronal nets in brain aging: an anatomical point of view; 16. Grey-matter networks in aging; 17. Brain synapse-related proteins what they do and how they change in aging; 18. Macro- and chaperone-mediated autophagy in aging; 19. Neuronal L-type calcium channels in aging; 20. D-serine-regulated glutamatergic transmission and microglia: impact of aging; 21. Voltage-gated potassium channels and the aging brain; 22. Dendritic spine remodeling and aging; 23. High-density lipoprotein-cholesterol and neuroaging: memory, gyrification of the insular and frontal opercular cortex; 24. Astrocyte and microglial aging: morphology and modelling; 25. Neural scaffolding: features, profiles and the aging cerebellum; 26. BACE1 RNAi, memory and aging; 27. Aging, myelination and the optic nerve; 28. Linking proteostasis, brain aging, and ischemia; 29. Luteinizing hormone and the aging nervous system; 30. Insights into aging using transcranial magnetic stimulation; 31. Alpha rhythms: What they are and how they alter with aging; 32. Nicotine and its derivatives in healthy brain aging III. Physiological Aspects 33. Environmental enrichment and physiological aging; 34. Treadmill exercise and neuroinflammation: links with aging; 35. Impact of aerobic exercise on brain structure in models of aging: hippocampus and beyond; 36. The physiology of fitness and the brain in aging; 37. Aging, Babble Noise and the processing of speech perception; 38. The blood-brain barrier in aging IV. Behavior And Psychopathological Aspects 39. Linking aging, anticholinergic drug use, and cognitive impairment; 40. Cognitive Frailty: Definition, components and impact on disability, and mortality; 41. The physiology of the Brain-muscle loop in aging; 42. Disentangling the effects of aging and ovarian hormone loss on sleep: Implications for health and disease; 43. Role of DNA methylation in aging-related cognitive functioning'; 44. Depression in the elderly and psychobiotics V. Diet And Nutrition 45. Aging, dietary patterns and cognition; 46. Geriatric nutritional risk index: Application, and limitations; 47. Diet, inflammatory biomarkers, and brain aging; 48. DASH diet and brain aging; 49. The ketogenic diet and healthy brain aging; 50. Autophagy and aging: diet, exercise, and the link with the target of rapamycin complex 1 (TORC); 51. Dietary Flavonoids and Brain Health in Ageing: food for Thought; 52. Antioxidant effects of curcumin and neuroaging; 53. Lipoic acid and vitamin D3 and their use in preventing brain aging; 54. Aging and working memory: Impact of the leucine metabolite beta hydroxy-beta-methyl butyrate; 55. Hydration, the brain and aging
- ISBN: 978-0-12-818369-4
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 1352
- Fecha Publicación: 25/06/2021
- Nº Volúmenes: 1
- Idioma: Inglés