Zika Virus Impact, Diagnosis, Control, and Models: Volume 2: The Neuroscience of Zika Virus

Zika Virus Impact, Diagnosis, Control, and Models: Volume Two: The Neuroscience of Zika examines diagnosis, vaccines, and potential therapy methods for Zika virus syndrome. The book also details the neuroscience of Guillain-Barré syndrome, its effects and neuromuscular rehabilitation. It is designed to help readers better understand detection, therapies for Zika virus, preventative vaccines, diagnosis and associated microcephaly. Chapters on models enable further research and understanding. This book has applicability for neuroscientists, neurologists, virologists and anyone working to better understand the evolution and pathogenesis of Zika virus-related conditions. Provides a broad range of topics related to the neuroscience of Zika, including its diagnosis, vaccines and therapy Contains chapter abstracts, key facts, a dictionary of terms and summary points to aid in understanding Discusses novel and non-pharmacological therapies, Guillain-Barré Syndrome and vaccine development Features chapters on rat, mouse, and guinea pig models of Zika and case reports of Zika co-infection with chikungunya, dengue-2 and Guillain-Barré Includes coverage of microcephaly and developmental delays and examines Zika outbreaks in Brazil, Honduras, Uganda, Jamaica and Mozambique INDICE: Section 1 - Methods, Biomarkers, and Diagnosis 1. Imaging Zika virus infection 2. Use of CRISPR: applications to flaviviruses 3. Methods of investigating neurotoxicity of larvicides: applications of systems biology 4. Methods for the detection of Zika virus infectivity Section 2 - Vector Control, Vaccines, Pharmacology 5. Vector control and Zika virus: a focus on mosquitoes 6. Vector control: a focus on rural household containers: applications to Zika virus 7. Zika virus Vaccines: an overview 8. Novel treatment with 2,8-bis(trifluoromethyl)quinoline analogs in Zika infection in vitro 9. Zika virus use of human neutralizing antibody in microcephaly prevention: a modelling system 10. Policies on Zika virus Control Section 3 - Novel and Non-Pharmacologic Therapies 11. Role of the pediatric neurologist in treating Zika virus syndrome 12. 25-Hydroxycholesterol usage in Zika Virus Infection 13. Screening and inhibition of the flavivirus NS2B-NS3 protease: application to zika virus 14. Gene silencing and applications to zika virus 15. Screening phytochemicals that react against Zika virus Section 4 - Models and Modelling 16. Guinea pig model of Zika virus: features and applications 17. Rat model of Zika virus: features and applications 18. Mouse model of Zika virus: features and applications 19. Modelling Zika virus in the USA 20. Modelling Zika virus infection in laboratory animals: impact on neurological systems Section 5 - Neuroscience of Guillain-Barré Syndrome 21. Severe Guillain-Barré Syndrome 22. Plasmablasts, plasma and neurotoxic antibodies in Guillain-Barré syndrome 23. Oxidative stress in Guillain-Barré Syndrome and linkage with neurology 24. Neuromuscular effects and rehabilitation in Guillain-Barré syndrome 25. Post-infectious demyelinating diseases: Guillain-Barré syndrome and beyond Section 6 - Neuroscience of Microcephaly 26. Microcephaly and developmental delays 27. Congenital microcephaly: features and risk factors 28. Microcephaly in fetal alcohol syndrome 29. Microcephaly in genetic disorders: the case of MFSD2A and hypomyelination 30. Folate metabolism, 5,10-methenyltetrahydrofolate synthetase and microcephaly Section 7 - International Aspects 31. Zika Virus in Honduras 32. Zika Virus in Uganda 33. Zika Virus in Jamaica 34. Zika virus in Mozambique 35. Zika virus in Brazil Section 8 - Case Reports 36. Case reports: Zika and Chikungunya virus infection 37. Case reports: Zika virus neuroretinitis 38. Case reports: Zika virus infection in Singapore 39. Case reports: Coinfection with Zika virus and dengue-2 viruses 40. Case report: Guillain-Barré and Zika virus infection

• ISBN: 978-0-12-820267-8
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 554
• Fecha Publicación: 12/07/2021
• Nº Volúmenes: 1
• Idioma: Inglés