Controlled Drug Delivery: The Role of Self-Assembling Multi-Task Excipients

In complex macromolecules, minor modifications can generate major changes, due to self-assembling capacities of macromolecular or supramolecular networks. Controlled Drug Delivery highlights how the multifunctionality of several materials can be achieved and valorized for pharmaceutical and biopharmaceutical applications. Topics covered in this comprehensive book include: the concept of self-assembling; starch and derivatives as pharmaceutical excipients; and chitosan and derivatives as biomaterials and as pharmaceutical excipients. Later chapters discuss polyelectrolyte complexes as excipients for oral administration; and natural semi-synthetic and synthetic materials. Closing chapters cover protein-protein associative interactions and their involvement in bioformulations; self-assembling materials, implants and xenografts; and provide conclusions and perspectives. Offers novel perspectives of a new concept: how minor alterations can induce major self-stabilization by cumulative forces exerted at short and long distancesGives guidance on how to approach modifications of biopolymers for drug delivery systems and materials for implantsDescribes structure-properties relationships in proposed excipients, drug delivery systems and biomedical materials INDICE: List of figuresList of tablesBiography for book1. The concept of self-assembling and the interactions involved 1.1 The concept of self-assembling1.2 The nature of forces and types of interactions involved in self-assembly of macromolecules1.3 Hydrogels and their role in drug conception and development1.4 Self-assembling phenomena in solid dosage forms1.5 ConclusionsReferences2. Starch and derivatives as pharmaceutical excipients: From nature to pharmacy 2.1 General aspects2.2 Structural considerations2.3 Self-assembling in physically modified starches2.4 Chemically modified starches and their self-assemblingReferences3. Chitosan and its derivatives as self-assembled systems for drug delivery Abbreviations3.1 Introduction3.2 Unmodified chitosan-self-assembled thermogels3.3 Amphiphilic chitosan derivatives3.4 Amphiphilic/amphoteric chitosan derivatives3.5 ConclusionReferences4. Chitosan-based polyelectrolyte complexes as pharmaceutical excipients Abbreviations4.1 Introduction to chitosan-based polyelectrolyte complexes4.2 Chitosan-chondroitin sulfate PEC4.3 Chitosan-carboxymethyl starch PEC4.4 Chitosan-dextran sulfate PEC4.5 Chitosan-pectin PEC4.6 Chitosan-alginate PEC4.7 Chitosan complexed with other polysaccharides4.8 ConclusionReferences5. Self-assembling in natural, synthetic, and hybrid materials with applications in controlled drug delivery 5.1 General considerations5.2 Natural polysaccharides and their derivatives used in controlled drug release5.3 Self-assembling of synthetic polymers5.4 Hybrid materials obtained by self-assembling5.5 ConclusionsReferences6. Protein-protein associative interactions and their involvement in bioformulations 6.1 Introduction6.2 Generalities on proteins, their roles, and their possible use as excipients6.3 Albumin microspheres and nanoparticles for drug delivery6.4 Self-assembling processes involving albumin and bioactive agents6.5 Collagen: generalities and utilizations as material for biopharmaceutical applications6.6 Protein excipients for solid dosage forms6.7 Pharmaceutical solid, oral, high-loaded, and gastro-resistant dosage forms of therapeutic enzymes6.8 Gastro-resistant excipient-free pharmaceutical forms of therapeutic enzymes6.9 ConclusionReferencesIndex

• ISBN: 978-0-08-101574-2
• Editorial: Woodhead Publishing
• Encuadernacion: Rústica
• Páginas: 200
• Fecha Publicación: 30/06/2016
• Nº Volúmenes: 1
• Idioma: Inglés