Eosinophil Ultrastructure: Atlas of Eosinophil Cell Biology and Pathology

Eosinophil Ultrastructure: Atlas of Eosinophil Cell Biology and Pathology entirely focuses on eosinophils and their functional roles in inflammation, host defense, and normal homeostatic activities. The book explores the ultrastructure of human eosinophils, highlighting biological processes observed under normal, experimental, and pathological conditions. Created to fill a void in the eosinophil literature, the book includes an extensive array of electron microscopic images that illustrate the diversity of eosinophil morphology. While the atlas is a learning and teaching tool, it is mainly a helpful  resource for researchers to identify distinguishing features and structural changes that arise during studies of human eosinophils. The book also covers the ultrastructure of mouse eosinophils under normal and activation conditions and in the context of representative diseases. Gives guidelines to understand the human eosinophils in studies focused on structural biology, cellular immunology, innate and adaptive immunity, immune responses to pathogens, immunopathology, and inflammatory responses Provides a core of essential knowledge to identify both immature and mature eosinophils Comprises a representative compilation of the eosinophil ultrastructure during biological processes, such as activation and degranulation, mostly under experimental conditions Highlights eosinophil biological processes found in vivo during human diseases, thus providing a link between basic science and clinical aspects Helps identify distinguishing features and structural changes that arise during studies of human eosinophils after isolation from body fluids, while in cultures, or biopsies Explains the ultrastructural organization of mature and immature mouse eosinophils, highlighting the similarities/differences between them and human eosinophils INDICE: Preface SECTION I - THE CELL BIOLOGY OF HUMAN EOSINOPHILS Chapter 1 Introduction Chapter 2 Mature Eosinophils - General Morphology 2.1 Overview 2.2 Nucleus 2.3 Secretory Granules 2.4 Lipid Bodies 2.5 Eosinophil Sombrero vesicles (EoSVs) 2.6 Other Organelles and Structures 2.6.1 Endoplasmic Reticulum Chapter 3 Eosinophils as Secretory Cells 3.1 Overview 3.2 Classical and Compound Exocytosis 3.3 Piecemeal Degranulation 3.4 Cytolysis 3.5 Extracellular Vesicles Production Chapter 4 Eosinophil Activation 4.1 Overview 4.2 Ultrastructural Changes of Secretory Granules 4.3 EoSV Formation 4.4 Lipid Body Formation 4.5 Shape Changes 4.6 Extracellular Vesicle Production Chapter 5 Subcellular Localization of Immune Mediators and other Proteins 5.1 Overview 5.2 Major Basic Protein 5.3 Cytokines 5.4 Receptors 5.5 Tetraspanins 5.6 Galectin-10 5.7 Enzymes Involved in the Formation of Leukotrienes Chapter 6 Eosinophil Cell Death 6.1 Overview 6.2 Cytolytic Morphology - General Aspects 6.3 Cytolytic Morphology - ETosis 6.4 Apoptotic Morphology - General Aspects Chapter 7 Immature Eosinophils 7.1 Overview 7.2 About Immature and Mature Eosinophil Granules 7.3 Maturation stages of human eosinophils characterized by TEM SECTION II - EOSINOPHILS IN HUMAN DISEASES Chapter 8 Eosinophil-associated diseases 8.1 Overview 8.2 Allergic Airway Diseases 8.3 Skin Disorders 8.4 Hypereosinophilic Syndrome (HES) 8.5 Eosinophilic Granulomatosis with Polyangiitis (EGPA) 8.6 Gastrointestinal Disorders 8.7 Infectious Diseases 8.8 Tumors 8.9 Charcot-Leyden Crystals (CLCs) Formation SECTION III - THE CELL BIOLOGY OF MOUSE EOSINOPHILS Chapter 9 Ultrastructure of Mouse Eosinophils 9.1 Overview 9.2 Mature Mouse Eosinophils: General Morphology 9.3 Immature Mouse Eosinophils 9.4 Activation and Degranulation of Mouse Eosinophils 9.5 Mice in the Context of EADs References Credits Index

• ISBN: 978-0-323-99413-2
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 518
• Fecha Publicación: 24/04/2022
• Nº Volúmenes: 1
• Idioma: Inglés