Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging, and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses-including cancer and cardiovascular, metabolic, and neurodegenerative diseases-are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease. Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related diseaseProvides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences and life-course health and aging trajectoryApplies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan, relevant to researchers, clinicians, and students of epigenetics, genomic medicine, and biogerontologyFeatures chapter contributions by leading international experts INDICE: Section I. Epigenetic Mechanisms in Aging 1. DNA methylation and healthy human aging 2. Aging epigenetics: accumulation of errors or realization of a specific program? 3. Age-associated epigenetic drift 4. DNA methylation as a biomarker for chronological age 5. Epigenetic regulation of ageing: linking environmental inputs to genomic stability 6. Involvement of sirtuins in life-span and aging related diseases 7. The epigenetic regulation of mammalian telomeres Section II. Early-life epigenetic programming of aging trajectories 8. The impact of early nutrition on the ageing trajectory 9. Genetic factors and epigenetic mechanisms of longevity: current perspectives 10. DNA methylation in social insects: how epigenetics can control behavior and longevity Section III. Epigenetics of Aging-Associated Diseases 11. The epigenetics of neurodegeneration 12. Cardiovascular epigenetics: from DNA methylation to microRNAs 13. Cancer epigenetics Section IV. Transgenerational epigenetic inheritance of aging phenotype and longevity 14. Intergenerational epigenetic inheritance in animal models of developmental programming 15. Transgenerational epigenetic programming of metabolic syndrome 16. Transgenerational inheritance of longevity Section V. Epigenome-targeted therapies in gerocscience 17. Are epigenetic drugs for diabetes and obesity at our door step? 18. Epigenetic-related therapeutic challenges in cardiovascular disease 19. Development and classes of epigenetic drugs for cancer 20. Epigenetic drug discovery for Alzheimer's disease 21. Anti-aging epigenetic diets 22. MicroRNA expression altered by diet: can food be medicinal? 23. Drosophila as a model to study the epigenetic basis of aging Conclusions and Perspectives. Genetics and epigenetics of aging and longevity
- ISBN: 978-0-12-811060-7
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 464
- Fecha Publicación: 01/01/2018
- Nº Volúmenes: 1
- Idioma: Inglés