Theranostic Approach for Pancreatic Cancer

Theranostic Approach for Pancreatic Cancer modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property through introducing new strategies and drugs for tackling the disease. It brings information about ongoing research as well as clinical data about pancreatic cancer and provides detailed descriptions about diagnostic and therapeutic options for easy understanding. This book discusses several topics related to pancreatic cancer such as stem cells, drug resistance and pancreatic tumor microenvironment, the latest developments in chemotherapy for metastatic cancer and chemoprevention, and epigenome as a therapeutic strategy. Additionally, it encompasses a discussion on theranostic clinical applications for personalized treatment and management of pancreatic cancer. The book is a valuable resource for cancer researchers, oncologists, and several members of the biomedical field who need to understand more about the diagnosis and treatment of pancreatic cancer. Provides information on the roadblocks of chemotherapy in patients with newly diagnosed and metastatic pancreatic cancerDiscusses treatment options available currently as well as prospective options for the futureFocuses especially on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways as already tested types of treatment INDICE: 1. Biology, pathophysiology and epidemiology of pancreatic cancer2. Diagnosis of pancreatic cancer 3. Current knowledge on drug resistance and therapeutic approaches to eliminate pancreatic cancer stem cells4. Drug resistance and microenvironment in pancreatic cancer 5. The role of tumor microenvironment in the metastasis of pancreatic cancer and immunotherapy 6. Latest developments in chemotherapy for metastatic pancreatic cancer 7. Genetic manipulations with chemotherapy in pancreatic cancer 8. Genetic predisposition for pancreatic cancer9. Pancreatic cancer resistance to chemotherapy: Resensitization strategies using resveratrol10. Anti-cancer activity of a small molecule, tolfenamic acid: An emphasis on pancreatic cancer11. Targeting the epigenome as a therapeutic strategy for pancreatic tumors - Non-coding RNAs and chromatin remodelers 12. Pancreatic cancer chemoprevention: A review on molecular pathways involved in carcinogenesis and targeting with terpenoids, a new potential anti-tumor drugs13. Meta-analysis on MTHFR polymorphisms and pancreatic cancer susceptibility 14. Therapeutic vaccines for pancreatic cancer 15. Epidermal growth factor receptor role in pancreatic cancer 16. Recent advances in molecular diagnostics and therapeutic targets for pancreatic cancer

• ISBN: 978-0-12-819457-7
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 420
• Fecha Publicación: 01/01/2020
• Nº Volúmenes: 1
• Idioma: Inglés