MicroRNA in Human Malignancies offers a deep overview of the role and translational significance of miRNAs in the development of cancer and other malignancies. The book establishes the foundations of the field by covering essential mechanisms and the translational potential of miRNAs in the field of oncology. Specific topics covered include invasion and metastasis, miRNAs and metabolism, and opportunities of miRNAs in therapeutics. Chapters on diseases include content on disease-related pathophysiology, as well as diagnostic, prognostic and predictive value. This book is an essential reference for students entering the field, as well as researchers and investigators. Provides fundamental and translational chapters that facilitate the acquisition of knowledge needed to design and perform innovative miRNA-related research studies Synthesizes current research, with a critical review on the field Offers in-depth research by leading experts in the field INDICE: SECTION 1: miRNAs involvement in basic mechanisms of cancer development 1. Overview on miRNA classification, biogenesis, and functions 2. microRNA in cancer: overview 3. miR-15/16 in human malignancies 4. microRNAs and TP53 regulation 5. microRNAs involvement in Invasion and metastasis 6. microRNAs and metabolism 7. microRNAs in inflammation processes SECTION 2: miRNAs methodologies 8. Wet-lab methods for miRNA analysis 9. Bioinformatics utilities, web resources and integrative strategies for the analysis of miRNA regulatory networks 10. Computational Resources for Analysis of miRNA Targetome 11. miRNA bioinformatics and pathway analysis SECTION 3: miRNAs involvement in therapeutics / theranostics 12. Opportunities of miRNAs in cancer therapeutics SECTION 4: miRNAs involvement in human cancer: pathophysiology and translational opportunities 13. Pathophysiology roles and translational opportunities of miRNAs in acute leukemias 14. Pathophysiology roles and translational opportunities of miRNAs in CLL 15. Pathophysiology roles and translational opportunities of miRNAs in Lymphoma 16. Pathophysiology roles and translational opportunities of miRNAs in Breast cancer 17. Pathophysiology roles and translational opportunities of miRNAs in colorectal cancer 18. Pathophysiology roles and translational opportunities of miRNAs in Lung cancer 19. Pathophysiology roles and translational opportunities of miRNAs in Mesothelioma 20. Pathophysiology roles and translational opportunities of miRNAs in Renal cancer 21. Pathophysiology roles and translational opportunities of miRNAs in Pancreatic cancer 22. Pathophysiology roles and translational opportunities of miRNAs in Prostate cancer 23. Pathophysiology roles and translational opportunities of miRNAs in Hepatocarcinoma 24. Pathophysiology roles and translational opportunities of miRNAs in Ovarian cancer 25. Pathophysiology roles and translational opportunities of miRNAs in Bladder cancer 26. Pathophysiology roles and translational opportunities of miRNAs in Cutaneous Melanoma 27. Pathophysiology roles and translational opportunities of miRNAs in Brain tumors 28. Pathophysiology roles and translational opportunities of miRNAs in Sarcomas
- ISBN: 978-0-12-822287-4
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 432
- Fecha Publicación: 17/02/2022
- Nº Volúmenes: 1
- Idioma: Inglés