We are changing our concept that the newborn infant emerges from a sterile environment. In-utero colonization may have major impacts on the developing mammal in terms of development of immunity and metabolism that, with epigenetic modifications, will lead to diseases in later life. In addition, the microbial profile that develops during and after birth depends on mode of delivery, type of feeding (human milk versus formula) and various other environmental factors to which the newborn is exposed. The Microbiome in Prenatal and Neonatal Life clarifies that the microbiome in the maternal fetal unit as well as the immediate changes that occur as new microbes are acquired postnatally play major roles in subsequent health and disease. Rapidly developing technologies for multi-omic analyses and systems biology are shifting paradigms in both scientific knowledge and clinical care. Discusses the critical nonredundant time frame in a newborn's life during which many factors drive immune and tissue maturation and influence the susceptibility to immune-mediated and other diseases in adult lifeProves that the fetus and uterine membranes are exposed to not only microbes in close proximity but also to microbial products from metabolism of microbes in the motherShows that since early life periods are a critical window for development, epigenetic and/or immunologic alterations may occur that can affect not only the infant during his/her lifetime but also subsequent generationsGives insight into factors that may affect the newborn microbiome and subsequent development INDICE: 1. Multi-omic effects on gametes and the early developing fetus2. The Prenatal Microbiome: is the In-Utero Environment Sterile?3. The Microbiome during Pregnancy: Putative Effects on the Developing Fetus4. Delivery Mode (C-section vs. Vaginal) and the Developing Microbiome 5. Development of the Microbiome and multi-omics in the Preterm Infant: Effects of the NICU Environment, Diet, Stress, Drugs, and Maternal Factors6. The Human Milk Microbiome and Metabolome: Effects on the Newborn and Infant7. Environmental Effects on the Developing Microbiome in the Fetus in Infancy8. The Skin Microbiome and Effects on Health and Disease9. The Developing Microbiome and the Brain10. The Developing Microbiome and the Lung11. The Developing Microbiome and the Heart
- ISBN: 978-0-12-820590-7
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 250
- Fecha Publicación: 01/12/2020
- Nº Volúmenes: 1
- Idioma: Inglés