As sites of action for drugs used to treat schizophrenia and Parkinson’s disease, dopamine receptors are among the most validated drug targets for neuropsychiatric disorders. Dopamine receptors are also drug targets or potential targets for other disorders such as substance abuse, depression, Tourette’s syndrome, and attention deficit hyperactivity disorder. Updated from the successful first edition, 'The Dopamine Receptors' serves as a reference work on dopaminereceptors while also highlighting the areas of research that are most active today. To achieve this goal, authors have written chapters that set a broad area of research in its historical context, rather than focusing on the researchoutput of their own laboratories. Relies heavily on new knowledge The use of knock-out mice and subtype-selective drugs merit discussion in stand-alone chapters The field of G protein-coupled receptors has advanced significantly since the publication of the first edition, with a model of GPCR signaling based on linear, compartmentalized pathways having been replaced by a more complex, richer model in which neurotransmitter effects are mediated by a signalplex composed of numerous signaling proteins, including multiple GPCRs, other types ofreceptors, such as ionotropic receptors, accessory and scaffolding proteins, and effectors Key aspects of this advanced model are specifically addressed innew chapters on dopamine receptor-interacting proteins and on dopamine receptor oligomerization INDICE: Historical Overview/Introduction to the Dopamine Receptors.- Gene and Promoter Structures of the Dopamine Receptors.- Structural Basis of Dopamine Receptor Activation and Function.- Dopamine Receptor Subtype-Selective Drugs: D2-like Receptors.- Dopamine Receptor Subtype-Selective Drugs: D1-like Receptors.- Dopamine Receptor Signaling: Intracellular Pathways to Behavior.- Dopamine Receptor Signaling: Physiology.- Regulation of Dopamine Receptor Trafficking and Responsiveness.- Dopamine Receptor Interacting Proteins (DRIPS).- Dopamine Receptor Oligomerization.- Dopamine Receptor Knockout mice.- Dopamine Receptors and Behavior.- Imaging Dopamine Receptors in Normal and Disease States.- Dopamine Receptor Modulation of Glutamatergic Neurotransmission.- Dopamine Receptors and the Treatment of Schizophrenia.- Dopamine Receptors and Cortical/Cognitive Function.- Dopamine Receptors and Reward/Addiction.- Genetic Association of Dopamine Receptors with Neuropsychiatric Disorders.
- ISBN: 978-1-60327-332-9
- Editorial: Humana
- Encuadernacion: Cartoné
- Páginas: 450
- Fecha Publicación: 01/11/2009
- Nº Volúmenes: 1
- Idioma: Inglés