Metabolic Phenotyping in Personalized and Public Healthcare

Metabolic Phenotyping in Personalized and Public Healthcare provides information on the widespread recognition that a personalized or stratified approach to patient treatment may offer a more efficient and effective healthcare solution than phenotype-led approaches. In order to achieve that objective, a deep personal description is required at the level of the genome, proteome, metabolome, or preferably a combination of these aided by technology. This book, edited and written by the outstanding luminaries of this evolving field, evaluates metabolic profiling and its uses across personalized and population healthcare, while also covering the advent of new technology fields, such as surgical metabonomics. In addition, the text presents specific examples of where this technology has been used clinically and with efficacy, pointing towards a framework and protocol for usage as it hits the clinical mainstream. Translates the conjunction of new surgical tools for intraoperative, real-time, metabolite evaluation and direct analysis of biofluid samples into novel options for augmented clinical decision-makingDiscusses longitudinal sampling from individual patients for stratified medicine Covers high resolution analytical spectroscopy and sophisticated computational modelling for prediction of adverse reactions in critical care scenarios, prognostic evaluation of cancer from biofluidism, and prognostic prediction of metabolism or response of patients to pharmaceutical interventions Encapsulates recent technology options for broader population profiling considerations, in particular, the metabolome-wide association studies (MWAS) that aid the translational researcher in identifying metabolic patterns associated with disease INDICE: 1: Unmet Medical Needs 2: An Historical Perspective 3: The Patient Journey 4: Surgical Spectroscopy 5: High Throughput Metabolic Screening 6: Pharmacometabonomics 7: Population Phenotyping, Exposomics, and MWAS 8: Handing on Health to the Next Generation 9: Addressing the Needs of an Aging Population 10: Phenome Centres and Global Harmonization 11: Leaving a Legacy - Databases to Big Data 12: Modeling People and Populations: Data Visualization 13: Future Visions

• ISBN: 978-0-12-800344-2
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 304
• Fecha Publicación: 01/09/2015
• Nº Volúmenes: 1
• Idioma: Inglés