This monograph begins with a general description of the cytoskeleton in axonal development and pathology and then moves to more detailed descriptions of particular components, including microtubules and associated proteins, neurofilaments and interacting proteins, actin and its binding proteins, and glial fibrillary acidic protein. The later chapters focus on the functional significanceof the neuronal cytoskeleton in axonal transport and its regulation in healthand disease states. The Cytoskeleton of the Nervous System will encourage further development of unifying principles and stimulate new conceptual and technical approaches toward a better understanding of cytoskeleton functions in health and disease. Describes cytoskeleton in axonal development and pathology, microtubules and associated proteins, neurofilaments and interacting proteins, actin and its binding proteins, and glial fibrillary acidic protein Focuses onfunctional significance of neuronal cytoskeleton in axonal transport Encourages further development of unifying principles, stimulates new conceptual and technical approaches toward a better understanding of cytoskeleton functions inhealth and disease INDICE: Central Axonal Development and Pathology in Early Life.- Microtubules in the nervous system.- Tau phosphorylation.- Tau Pathology.- Tauopathy and brain aging.- Microtubule-associated protein 4.- Structure of Neural Intermediate Filaments.- Alpha-internexin: the Fourth Subunit of Neurofilaments in the Mature CNS.- Peripherin Pathology.- Neurofilament cross-bridge: a structure associated specifically with the neurofilament among the intermediate filamentfamily.- Neurofilament Transport.- Knockout models of neurofilament proteins.- Neurofilaments and Radial Growth: Deconstruction of a hypothesis through theconstruction of gene targeted mice.- Deregulation of Cytoskeletal Protein Phosphorylation and Neurodegeneration.- Neurofilaments in Aged Animals.- Neurofilament changes in Multiple Sclerosis.- Intermediate filament interactions in neurons.- Tropomyosins in Neuronal Morphogenesis and Development.- The Driving Machinery for Growth Cone Navigation.- Glial Fibrillary Acidic Protein: The intermediate filament protein of astrocytes.- Axonal Transport Mechanisms in Cytoskeleton Formation and Regulation.- Axonal transport and motor neuron disease.- In vivo imaging of axonal transport in aging and Alzheimer's disease.- Regulation of Cytoskeletal Composition in Neurons: Transcriptional and Post-transcriptional Control in Development, Regeneration, and Disease.- Crosstalks between myelinating cells and the axonal cytoskeleton.- Topographic regulation of neuronal intermediate filament proteins by phosphorylation: In health and disease.- Cytoskeleton, axonal transport, and the mechanisms of axonal neuropathy.- Effects of Insulin on Tau and Neurofilament.- Ethanol effects on the cytoskeleton of nerve tissue cells
- ISBN: 978-1-4419-6786-2
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 1060
- Fecha Publicación: 29/11/2010
- Nº Volúmenes: 1
- Idioma: Inglés