With recent technological advances and mass-scale sequencing approaches, our understanding of lipid metabolism and signaling, and its role in health and disease processes, has increased significantly. The maintenance of metabolic health has been shown to require complex regulation of metabolic processes in several tissues, and extensive crosstalk among tissues and organs. Lipids act not only as constituents of cellular membranes, but as key signaling mediators, serving new and unexpected biological, metabolic, and cellular functions. Lipid Signaling and Metabolism provides foundational knowledge and methods to examine lipid metabolism and bioactive lipid signaling mediators that regulate a broad spectrum of biological processes and disease states. Here, world-renowned investigators, first offer a basic examination of general lipid, metabolism, intracellular lipid storage and utilization, followed by an in-depth discussion of lipid signaling and metabolism across disease areas, including obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease, and mood-related disorders. Throughout, authors demonstrate how expanding our understanding of lipid mediators in metabolism and signaling enables opportunities for novel therapeutics. Emphasis is placed on bioactive lipid metabolism and research that have been impacted by new technologies, and their potential to transform precision medicine. Provides a clear, up-to-date understanding of lipid signaling and metabolism and the impact of recent technologies critical to advancing new studiesEmpowers researchers to examine bioactive lipid signaling and metabolism, supporting translation to clinical care and precision medicineDiscusses the role of lipid signaling and metabolism in obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease, and mood-related disorders among other diseases INDICE: PART I LIPID METABOLISM 1. Lipid Metabolism: Location, Location 2. Lipolysis in Lipid Metabolism and Signaling 3. Regulation and Function of Phospholipid Metabolism 4. Sex differences in lipid metabolism 5. Regulation of Intracellular Lipid Storage and Utilization 6. Lipid Metabolism in Aging 7. Autophagy and Lipid Metabolism 8. The Microbiome and Lipid Metabolism 9. Lipid Metabolism in obesity and Diabetes 10. Transcriptional regulation of Lipid metabolism 11. Metabolic Control by lipid Droplet proteins 12. Lipid metabolism in cardiovascular diseases conditions 13. Control of Lipid Metabolism in Insulin resistant States 13. lipid metabolism in Cancer and their microenvironment 14. Adipocyte differentiation and metabolism PART II LIPID-MEDIATED SIGNALING 15. Lipid Metabolites as signaling molecules 16. Membrane Microdomains: Structure and Function 17. Fatty acid desaturation and lipid signaling 18. mTOR and lipid signaling 19. Phospholipid signaling 20. Adipose tissue derived lipids in Signaling 21. Lipoamines: An Emerging Class of Novel Lipid Signaling Molecules 22. Lipid signaling in brain in response to food 23. Proresolving lipid mediators that control inflammation 24. Fatty Acids in prevention and therapeutics 25. Sphingolipid mediators in non-alcoholic fatty liver disease 26. Bile Acid Signaling 27. Lipids in Skin Physiology Health and Disease 28. Lipid Factors: Activators of nuclear receptors and of G-protein coupled receptors 29. The biology of adipose tissue and adipocyte signaling
- ISBN: 978-0-12-819404-1
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 480
- Fecha Publicación: 01/08/2020
- Nº Volúmenes: 1
- Idioma: Inglés