Mitochondrial Intoxication explores the effects toxic molecules can have upon mitochondrial physiology in the human body. Each chapter is dedicated to a specific toxicant, including pollutants, food additives, illicit and pharmaceutical drugs, and heavy metals. This book considers the implications and impact these have upon mitochondria and the diseases that can result from dysfunction and impairment in the human body. Furthermore, the book provides an overview of mitochondrial physiology and assesses the advances and challenges in testing mitochondrial toxicity. Case studies exploring mitochondrial intoxication in pregnancy and in the geriatric population are also included. This is a comprehensive reference on the main toxicants impacting mitochondria in the human body, and the consequences this can have for health and disease. Features a wide range of toxicants and their effects on mitochondrial physiology Covers molecular markers of mitochondrial intoxication Includes case studies that illustrate the health impacts of toxicity upon mitochondria Considers future directions regarding the study of mitochondrial intoxication INDICE: 1. Mitochondrial physiology: An overview 2. Molecular markers of mitochondrial intoxication 3. Drug-induced mitochondrial impairment: Mechanisms and testing systems 4. Challenges in mitochondrial profiling during pre-clinical studies 5. Acrylamide 6. The effects of air pollution toxicants on the mitochondria 7. Aflatoxin B 8. The effects of the alcohol abuse against the mitochondria. Functional consequences for liver, muscle, and the brain 9. Aluminum 10. Discovery of amiodarone mitochondrial toxicity in liver and beyond 11. Ammonia 12. The mitochondrial disruption as a contributing factor for the neurotoxicity of amphetamines 13. Anthracycline 14. Antidepressants, mood stabilizing drugs and mitochondrial function; for better or for worse 15. The effects of antiretroviral drugs on the mitochondria 16. Arsenic 17. Mechanisms of bisphenol A toxicity in mitochondria 18. Chemotherapeutic drugs 19. Cuprizone 20. Delta-9-tetrahydrocannabinol (Cannabis sativa) 21. Diclofenac 22. Food additives 23. Mitochondria as a toxicological target for fungicides 24. The effects of methylglyoxal on the mitochondria 25. The effects of mercury on the mitochondria 26. Organohalogens 27. The effects of organophosphate pesticides on the mitochondria 28. Oxygen toxicity 29. Paracetamol/Acetaminophen 30. Plant molecules (Mitochondrial intoxication induced by plant molecules) 31. Polychlorinated biphenyls (PCBs) 32. The effects of polycyclic aromatic hydrocarbons on the mitochondria 33. Pyrethroids 34. Redox cycling compounds (Mitochondrial toxicity of redox cycling compounds) 35. The effects of sodium nitrate on the mitochondria 36. Zinc
- ISBN: 978-0-323-88462-4
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 765
- Fecha Publicación: 01/12/2022
- Nº Volúmenes: 1
- Idioma: Inglés