Molecular Nutrition and Mitochondria: Metabolic Deficits, Whole-Diet Interventions, and Targeted Nutraceuticals

Molecular Nutrition and Mitochondria: Metabolic Deficits, Whole-Diet Interventions, and Targeted Nutraceuticals provides a comprehensive examination of molecular aspects of mitochondrial nutrition and how dietary compounds might impact the treatment of mitochondrial dysfunction. Beginning with an overview of the fundamentals of mitochondria physiology and the methods used to evaluate mitochondrial imbalance in clinical practice, the book goes on to outline nutritional shortfalls in mitochondrial dysfunction and highlights the complex intra-organelle milieu affecting interactions between food compounds and mitochondrial co-factors, metabolites, and signaling molecules. Further sections explore the impact of essential nutrients, such as vitamin E, fatty acids, and complex lipids, on mitochondrial biogenesis, as well as non-essential bioactive compounds originating from food that can be evaluated for their mitochondria-modulating potential, such as mitochondria-targeted small molecule antioxidants, plant-based pigments and organic compounds, nucleotides, non-proteogenic amino acids and derivatives, and mitochondria-specific enzyme mimetics from food. Molecular Nutrition and Mitochondria covers the key impacts of nutrition on mitochondria, and is the ideal reference for researchers, students and clinicians looking to develop an in-depth understanding of how dietary compounds can prevent and treat disorders associated with mitochondrial dysfunction. Describes the fundamentals of mitochondria physiology and considers the methods used to evaluate mitochondrial imbalance in clinical practice Provides broad biochemical and metabolic background on nutritional deficits found in mitochondrial dysfunction Explores the prevention and treatment of various inherited and acquired disorders associated with mitochondrial dysfunction Discusses the link between the dosage for each nutrient (nutritional vs. pharmacological) and the clinical effect Features a dedicated section on whole-diet interventions and mitochondrial function INDICE: SECTION I1. Nutritional Support in Mitochondrial Diseases: The State of the Art2. Targeting Mitochondrial Dysfunction: Challenges and Opportunities3. Impact of Mitointeractions On Health-Disease Responses to Diet4. Mitochondrion at the Crossroads Between Nutrients and Epigenome5. Inadequate Nutritional Intake in Mitochondrial Diseases6. Nutritional Deficits Involved in Mitocondrial Damage in Critical IllnessSECTION II7. Mitochondrial Response to Controlled Nutrition in Health and Disease8. Diet Restriction-Induced Mitochondrial Signalling and Healthy Aging9. Ketogenic Diets, Mitochondria, and Neurological diseases10. Ferility Diet and Mitochondrial Function11. Maternal Nutrient Modulation and Fetal Mitochondrial Gene Expression12. Dietary Modulation and Mitochondrial DNA DamageSECTION III13. Vitamin E, Mitochondrial Dysfunction and Aging14. The Role of B Vitamins in Protecting Mitochondrial Function15. Triggering Mitochondrion-Dependent Necrosis by Fatty Acids16. Dietary Lipids and Mitochondrial Gene Expression17. Dietary EPA and DHA for Mitochondrial Biosynthesis and Dynamics18. Supplemental Vitamin C for Mitochondrial Biogenesis in Health and ExerciseSECTION IV19. Mitochondria-Targeted Antioxidants: Coezyme Q10, MitoQ and beyond20. Flavonoids, Mitochondrial Enzymes and Heart Protection21. Tea Polyphenols Stimulate Mt Bioenergetics in Cardiometabolic Diseases22. Quercetin and Mitochondria: from Nutrition to Nanomedicine23. N-acetylcysteine and Up-Regulation of Mitochondrial Biogenesis24. Dietary Carnitine, Mitochondrial Function and Therapy25. Creatine Monohydrate for Mitochondrial Nutrition26. Benefits of Supplemental Arginine and Citrullne in MELAS syndrome27. Nutraceuticals for Targeting NAD+ to Restore Mitochondrial Function28. Curcumin for Protecting Mitochondria and Down Regulating Inflammation29. Dietary Molecular Hydrogen for Mitochondrial Viability30. Fucoxantin and Mitochondrial Uncoupling Protein-1 in Obesity31. Rice Bran Extract for the Prevention of Mitochondrial Dysfunction32. Dietary Modulators of Nuclear Factor Erythroid-2-Related Factor 233. Plant Silymarin Affects Mitochondrial Integrity in Stress Conditions34. Alternative Respiratory Chain Enzymes: Therapeutic Potential and Possible Pitfalls35. New Mitochondria Permeability Transition Pore Inhibitor Based on Dietary Gallic Acid36. Plant-Derived Compounds, Vitagens, and Mitochondrial Function37. Buckwheat Trypsin Inhibitor (rBTI): A Novel Nutrceutical for Mitochondrial Homeostasis in Age-Related Conditions38. Nutraceutical Effects of Indian Gooseberry on Mitochondria-Mediated Cellular Damage39. 5-Heptadecylresorcinol from Whol Grain Rye for Mitochondrial Bioactivities40. Combined Nutraceutical Therapy for Mitochondrial Cytopathies

• ISBN: 978-0-323-90256-4
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 650
• Fecha Publicación: 01/08/2022
• Nº Volúmenes: 1
• Idioma: Inglés