Genomic Surveillance and Pandemic Preparedness offers practical, in-depth instruction in where, how, and why genomic surveillance may be applied. Drawing heavily from learnings during the Covid-19 pandemic, this book covers viral genome sequencing analysis, implementation and inference of genomic surveillance, and global data sharing best practices for future pandemic preparedness. Here, more than a dozen international authors consider host and pathogen genome interaction, population-level prevalence, individual disease susceptibility and gene protection, pathogen mutation types and speeds, RNA modulation of infection, pathogen diversity, and the role of co-infections and co-morbidities in disease severity. A wide range of examples, from bacterial pathogens to fungal and viral infections, with an emphasis on recent Covid-19 analysis, are discussed. Finally, authors provide step-by-step instruction in experimental and computational approaches for genomic surveillance, including nucleic acid isolation, sequencing library preparation, functional sequencing analysis, and bioinformatics pipelines. Throughout the book, importance is placed on inference-moving from genomic sequencing to meaningful genomic surveillance that bolsters pandemic preparedness. Highlights different aspects of genomic surveillance, from theory to implementation to inferences Covers a broad range of infectious diseases, with emphasis on recent Covid-19 studies Shares methods and approaches for seque INDICE: Section A: Pathogens and Host: Genomics perspective 1. Population level differences in prevalence of different disease conditions, severity and clinical outcome 2. Role of different alleles or genes in disease susceptibility and protection 3. Pathogen mutations and their role in disease severity and clinical outcome 4. RNA as modulators infection outcome: Potential usage for genomic surveillance Section B: Pathogen Diversity 5.Viral Pathogens - diversity in terms of genetic backbone and transmission 6. Bacterial pathogens 7. Fungal infections Section C: Co-factors in addition to pathogen 8. Host response modulates disease severity 9. Role of co-infections in modulating disease sub-phenotype 10. Are co-morbidities important modulators of disease severity? 11. Environmental and wastewater surveillance Section D: Future pandemic preparedness 12. Disease burden on Public Health - learning from past and current for future 13. Experimental repertoire to explore the functional landscape 14. Computational approaches to understand and elucidate such interaction and outcome 15. Technologies enabling genomic surveillance Section E: Roadmap ahead 16. Interactions shaping the Interactome - Genomic surveillance inclusive of host and pathogen
- ISBN: 978-0-443-18769-8
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 450
- Fecha Publicación: 01/07/2023
- Nº Volúmenes: 1
- Idioma: Inglés