Direct Nose to Brain Drug Delivery: Mechanism, Technological Advances, Applications and Regulatory Updates

Direct Nose to Brain Drug Delivery: Mechanism, Technological Advances, Applications and Regulatory Updates provides the reader with precise knowledge about the strategies and approaches for enhanced nose to brain drug delivery. It highlights the development of novel nanocarrier-based drug delivery systems for targeted drug delivery to the brain microenvironments with a focus on the technological advances in the development of the novel drug delivery devices for intranasal administration, including special emphasis on brain targeting through nose. This book explores the various quantification parameters to assess the brain targeting efficiency following intranasal administration, includes an overview on the toxicity aspects of the various materials used to develop the direct nose to brain drug delivery vehicles and of the regulatory aspects including patents and current clinical status of the potential neurotherapeutics for the effective management of neuro-ailments. Technological advances in new drug delivery systems with diverse applications in pharmaceutical, biomedical, biomaterials, and biotechnological fields are also explained. Direct Nose to Brain Drug Delivery: Mechanism, Technological Advances, Applications and Regulatory Updates is a crucial source that will assist the veteran scientists, industrial technologists, and clinical research professionals to develop new drug delivery systems, and novel drug administration devices for the treatment of neuro-ailments. Explains the targeting approaches for enhanced brain targeting following intranasal drug administrationExplores the various nanocarriers developed to date for neurotherapeutic delivery via nose to brainDiscusses pharmaceutical and biomedical applications after nose to brain delivery of therapeutic pharmaceuticals and biologicals INDICE: Section-I: Basic considerations 1. An overview of the anatomy and physiology of the nose 2. An overview of the anatomy and physiology of the brain 3. Major challenges in the brain targeted drug delivery: BBB and other CNS barriers 4. Approaches for enhanced brain targeting following intranasal drug administration Section-II: Nanotechnology and Naso-brain drug delivery 5. Emerging nanotechnologies for CNS targeting 6. Nanotechnological advances in direct nose to brain drug delivery for neurodegenerative disorders and other neuro-ailments 7. Surface-modification of nanocarriers as a strategy to enhance the direct nose to brain drug delivery 8. Mucoadhesion as a strategy to enhance the direct nose to brain drug delivery Section-III: Carriers for direct nose to brain drug delivery 9. Particulate carriers for direct nose to brain drug delivery 10. Vesicular carriers for direct nose to brain drug delivery Section-IV: Applications of direct nose to brain drug delivery 11. Applications of direct nose to brain drug delivery in medicine and pharmacy 12. Applications of direct nose to brain drug delivery in biomedicine, biotechnology, tissues engineering and immunology 13. Diagnostic or theranostic applications in brain targeted drug delivery Section-V: Devices for effective drug administration 14. Drug delivery devices for effective intranasal drug administration Section-VI: Models for direct nose to brain drug delivery 15. In vitro, ex vivo, and in vivo models for direct nose to brain drug delivery Section-VII: Toxicity and Regulatory aspects 16. Toxicity aspects 17. Regulatory aspects

• ISBN: 978-0-12-822522-6
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 475
• Fecha Publicación: 01/06/2021
• Nº Volúmenes: 1
• Idioma: Inglés