Malaria is a deadly disease which threatens half of the world's population. Advances over the last decade have seen vast improvements in the effectiveness of both preventative measures and treatments, but the rapid adaptability of the disease means that the ongoing search for improved and novel antimalarial drugs is essential. The Design and Synthesis of Antimalarial Agents aims to support medicinal chemists in this search, providing practical guidance on current developments and highlighting promising leads for the future. Beginning with a focus on biological aspects of malaria, early chapters include a description of the lifecycle of the parasite responsible for malaria, the problem of resistance, combinational therapy, genetic mapping of the parasite's genome, established drug targets, and potential drug targets for the future. The book then goes on to cover the medicinal chemistry of antimalarial agents in detail, with a focus on the design of antimalarial drugs supported by a review of the drug categories that have reached the market, as well as those in the pipeline. Finally, the synthesis of different classes of antimalarial agents is reviewed, including a discussion on chemical and process development. Drawing on the knowledge of its expert authors, The Design and Synthesis of Antimalarial Agents is a comprehensive yet accessible guide for all those involved in the design, development and administration of antimalarial drugs. Consolidates current developments in the discovery, design and synthesis of antimalarial drugs for the first timePresents content in a style that is both thorough and engaging, supporting and encouraging students and researchers from interdisciplinary backgroundsHighlights which drug targets are currently considered to be the most promising for future therapies, and the classes of compounds that are currently being studied and perfected INDICE: 1. Historical overview of malaria and its treatment 2. Knowing one's enemy: Microbiology, genetics, life cycle and resistance mechanisms of the parasite 3. Drug targets and their rationale 4. Testing procedures 5. The cinchona alkaloids and the aminoquinolines 6. Artemisinin and artemisinin-related agents 7. Agents acting on pyrimidine metabolism (triazolopyrimidines) 8. Agents inhibiting haemoglobin hydrolysis (pyrimidine carbonitriles) 9. Antibiotics 10. Drugs targeting mitochondrial functions 11. Miscellaneous agents 12. Bio inorganic agents 13. Synthesis of aminoquinolines 14. Synthesis of artemisinin and related structures 15. Synthesis of other antimalarial agents
- ISBN: 978-0-08-101210-9
- Editorial: Elsevier
- Encuadernacion: Rústica
- Páginas: 516
- Fecha Publicación: 01/04/2018
- Nº Volúmenes: 1
- Idioma: Inglés