Biomarkers in Kidney Transplantation: Clinical Aspects and Laboratory Determinations provides a focused study on traditional and emerging biomarkers to predict early rejection of kidney transplant supporting appropriate therapeutic interventions. Coverage includes predictive and diagnostic biomarkers for different types of rejections including biomarkers of acute, chronic/sub chronic rejection or clinical rejection, both the types T-cell mediated rejection, antibody mediated rejection or mixed rejection. Comparisons are provided for broad classification of pharmacokinetic versus pharmacodynamic biomarkers; and differentiation is shown between the susceptibility, diagnostic, predictive, prognostic and monitoring biomarkers. Coverage of the analytical aspects of biomarker measurement, the process of biomarker discovery and their clinical validation addresses both the clinical features of biomarkers as well as the pitfalls of determining such biomarkers in clinical laboratories. By combining all current markers known for kidney transplant in one collection, this easy to use reference is perfect for pathologists, clinical pharmacologists and clinical laboratory scientists as well as all physicians involved in organ transplantation including immunologists and transplant surgeons. Comprehensive coverage of all available biomarkers to predict organ rejection is included with a detailed discussion of which biomarkers can be measured in clinical laboratories and which biomarkers are measured in research laboratories Guidance on how to interpret test results of all available biomarkers is provided Possible sources of errors in measuring biomarkers are discussed to eliminate issues of interference INDICE: 1. Organ transplantation : Past, Present and Future2. Trends in organ transplantation3. Immunobiology in organ transplantation4. Immunosuppression in solid organ transplantation5. Challenges in therapeutic drug monitoring of immunosuppressants6. Biomarkers in transplantation : An overview7. Biomarkers for risk of rejection8. Biomarkers predicting the response to immunosuppressant therapy9. Biomarkers predicting risk of recurrence of the primary renal disease10. Biomarkers for detecting opportunistic infections11. Biomarkers detecting organ toxicity with immunosupressant drugs12. Biomarkers for drug development in organ transplantation13. Commercially available biomarkers for renal transplantation14. The current challenges, unmet need and future directions
- ISBN: 978-0-12-824069-4
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 308
- Fecha Publicación: 01/09/2022
- Nº Volúmenes: 1
- Idioma: Inglés