DNA damage responses are integral to the repair of DNA and initiation of checkpoints that maintain genomic stability and prev. Seeks to summarize the current views of DNA damage recognition, to describe the major obstacles faced by researchers in this field, and also to predict the key issues that will be addressed in the next few years that will shape the future of basic research in cancer biology INDICE: ATR biochemistry.- ATM biochemistry.- ATM biochemistry, Xenopus extracts.- ATR bioschemistry Xenopus extracts.- ATM/ATR signaling related topicsand cell assays.- ATM, Brca1 cell based assays.- immunofluorescence-based techniques for looking at DSB signaling.- mouse modles.- mouse models.- mouse models.- checkpoint signaling at replication forks.- checkpoint adaptation.- checkpoint signaling.- chromatin and DSBs.- Brca2, Rad51 biochemistry.- signaling pathways and non-homologous, Xenopus extracts.- DNA PK and ATM DSB recognition.- DNA-PK/Ku DSB recognition.- NEJ,DSBR.- mismatch repair.- mismatch repair.- excision repair.- DSBR.- mismatch repair.
- ISBN: 978-0-387-69136-7
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 250
- Fecha Publicación: 01/05/2009
- Nº Volúmenes: 1
- Idioma: Inglés