Applications of Time-of-Flight and Orbitrap Mass Spectrometry in Environmental, Food, Doping, and Forensic Analysis

Applications of Time-of-Flight and Orbitrap Mass Spectrometry in Environmental, Food, Doping, and Forensic Analysis deals with the use of high-resolution mass spectrometry (MS) in the analysis of small organic molecules. Over the past few years, time-of-flight (ToF) and Orbitrap MS have both experienced tremendous growth in a great number of analytical sectors and are now well established in many laboratories where high requirements are placed on analytical performance. This book gives a head-to-head comparison of these two technologies that compete directly with each other. As users with hands-on experience in both techniques, the authors provide a balanced description of the strengths and weaknesses of both techniques. In the vast majority of cases, ToF-MS and Orbitrap-MS have been used for qualitative purposes, mainly identification of discrete molecular entities such as drug metabolites or transformation products of environmental contaminants. This paradigm is now changing as quantitative capabilities are increasingly being explored, as are non-target approaches for unbiased broad-scope screening. In view of the continuous innovation of high-resolution MS instrument manufacturers in designing and developing more powerful machines, technological advances in both hardware and software are considerable, with many novel applications. This book summarizes and analyzes these trends. The compilation of selected examples from diverse analytical fields will allow the readers to discover not only the potential of high-resolution MS in their sector, but also shows advances in other fields that rely on hi-res MS. Provides comprehensive coverage of applications of time-of-flight and orbitrap mass spectrometry in environmental, food, doping, and forensic analysisExplores a variety of specialized techniques, giving a balanced description of the strengths and weaknesses of eachPresents a general overview of imaging techniques within analysis INDICE: Instrumentation 1. Orbitrap Mass Spectrometry: Evolution and Applicability   Claudia P.B. Martins 2. Advances in Time of flight Mass Spectrometry   John Fjeldsted and Isidre Masana 3. Ambient Ionization-High Resolution Mass Spectrometry: Environmental, Food, Forensic and Doping analysis   Encarna Moyano Target analysis, identification, and suspect screening 4. High resolution mass spectrometry in doping control   Rosa Ventura 5. Application of LC-Time of Flight and Orbitrap-MS/MS for pesticide residues in fruits and vegetables   Amadeo Fernandez-Alba 6. Identification of sildenafil designer analogues found in dietary supplements   GE Xiaowei 7. High-resolution mass spectrometry in metabolite identification   Saranjit Singh 8. LC-TOF-MS for the Identification of Environmental Metabolites and Degradation Products   Imma Ferrer 9. Application of Orbitrap Mass Spectrometry for the Identification of Transformation Products of Trace Organic Contaminants Formed in the Environment   Thomas Ternes 10. High resolution-mass spectrometry identification of micropollutants transformation products produced during water disinfection with chlorine and related chemicals   José Benito Quintana 11. Discovery of New Emerging DBPs by High Resolution Mass Spectrometry   Susan Richardson 12. Suspect screening of pharmaceuticals and related bioactive compounds, their metabolites and their transformation products in the aquatic environment, biota and humans using LC-HR-MS techniques   Sandra Pérez, Jaume Aceña Sánchez and Piero R. Gardinali Non-target analysis 13. Non-target analysis of environmental samples based on liquid chromatography coupled to high resolution mass spectrometry (LC-HRMS)   Nikolaos Thomaidis 14. Non-targeted analysis of persistent organic pollutants by mass spectrometry and GC×GC   Eric Reiner 15. High resolution mass spectrometry in the effect-directed analysis of water resources   Martin Krauss Conclusions 16. Conclusions and future Directions   Sandra Pérez and Peter Eichhorn

• ISBN: 978-0-444-63572-3
• Editorial: Elsevier
• Encuadernacion: Rústica
• Páginas: 500
• Fecha Publicación: 01/06/2016
• Nº Volúmenes: 1
• Idioma: Inglés