Predictive Toxicology: From Vision to Reality

Tailored to the needs of drug developers, this one–stop reference for medicinal chemists covers all the latest developments in the field of predictive toxicology and its applications in safety assessment. With a keen emphasis on novel approaches, the topics have been tackled by selected expert scientists, who are familiar with the theoretical scientific background as well as with the practical application of current methods. Emerging technologies in toxicity assessment are introduced and evaluated in terms of their predictive power, with separate sections on computer predictions and simulation methods, novel in vitro systems including those employing stem cells, toxicogenomics and novel biomarkers. In each case, the most promising methods are discussed and compared to classical in vitro and in vivo toxicology assays. Finally, an outlook section discusses such forward–looking topics as immunotoxicology assessment and novel regulatory requirements. With its wealth of methodological knowledge and its critical evaluation of modern approaches, this is a valuable guide for toxicologists working in pharmaceutical development, as well as in safety assessment and the regulation of drugs and chemicals. INDICE: Introduction PART 1: IN SILICO TOXICOLOGY Introduction to in silico Toxicology Data Management and Bioinformatics Predictive Modeling and Simulation PART 2: ADVANCED IN VITRO SYSTEMS AND STEM CELLS Stem cells Liver Stem Cells In vitro systems in Nephrotoxicology Stem Cells in Neurotoxicology Stem Cells in Teratology The Zebra Fish Model PART 3: OMICS AND SAFETY BIOMARKERS Liver & Kidney Toxicogenomics Carcinogenesis and Hepatotoxicology Novel biomarkers of toxicity Advanced molecular biology and Safety Assessement PART 4: SPECIAL TOPICS Immunogenicity; Immunotoxicology Imaging Regulatory Aspects (Drugs, Chemicals, Cosmetics)

• ISBN: 978-3-527-33608-1
• Editorial: Wiley VCH
• Encuadernacion: Cartoné
• Páginas: 400
• Fecha Publicación: 24/11/2014
• Nº Volúmenes: 1
• Idioma: Inglés