This comprehensive overview of what is a vital area of scientific enquiry covers a broad spectrum of issues. With contributions from some of the key researchers in the field, Adult Stem Cells: Biology and Methods of Analysis offers readers historical perspective as well as unique insights into cutting-edge thinking. The volume contextualizes the recent discovery of stem/progenitor cell populations resident in many adult tissues and organs. It confronts the complexities scientists face in trying to validate these cells and describes and critically evaluates the methods currently used to assess stem cell self-renewal.The chapters also seek to distinguish this process from other aspects of cellsurvival, such as the regulation of life span, senescence, and immortalization at a molecular level. Beginning with a section examining the basic biology of adult stem cells, including chapters on the emerging role of microRNAs in regulating their fate and the molecular mechanisms that govern their self-renewal, the book moves on to analyze the varying methodologies employed in characterizing these elusive elements of our genetic make-up. This second section details in-vivo lineage tracing of tissue-specific stem cells, explores the neuralstem cell paradigm, and considers the function of ABC transporters and aldehyde dehydrogenase in adult stem-cell biology. The third section focuses on life-span regulation and immortalization and features a chapter on the cancer stemcell paradigm. This authoritative volume on one of the frontiers of genetic research will serve as a valuable resource, not just for established scientistsbut also for those now entering the field of stem cell biology. Provides an ample overview of adult stem cell biology The comprehensive nature of the volume and the unique insights provided by the contributing authors make it an important resource both for those interested in adult stem cell biology as well asresearchers working in the field Written by leaders in the field, the text provides both a historical prospective as well as detailed information regardingthe state-of-the-art in the field of adult stem cell biology INDICE: Preface.- Contributors.- Corresponding Authors.- Part I: Basic Biology of Adult Stem Cells .- Chapter 1: Molecular Mechanisms Regulating Adult Stem Cell Self-Renewal, D. M. Panchision.- Chapter 2: Maintenance of Adult StemCells: Role of the Stem Cell Niche, T. Suda.- Chapter 3: Emerging Role for microRNAs in Regulating Adult Stem Cell Fate, J.M. Shookhoff and G.I. Gallicano.- Chapter 4: Expression and Function of Pluripotency-Specific Genes in Adult Stem Cells, A. Lo Nigro, P. Roelandt and C. M. Verfaillie.- Chapter 5: Adult Stem Cell Plasticity Revisited, E. Mezey.- Part II: Characterization of Adult Stem Cells.- Chapter 6: Lineage Tracing of Tissue-Specific Stem Cells In Vivo, K. T. Sobush, K. Matsumoto, H. Chen, and B. R.Stripp.- Chapter 7: Surrogate Measure of Adult Stem Cells Self-Rewal: The Neural Stem Cell Paradigm, P. Deleyrolle, B.A. Reynolds and F.A. Siebzehnrubl.- Chapter 8 ABC Transporters, Aldehyde Dehydrogenase, And Adult Stem Cells, M. R. Allison.- Part III: Regulation ofLife Span and Immortalization.- Chapter 9 Regulation of Life Span in Adult Stem Cells, P. Davy and R. Allsopp.- Chapter 10 The cancer stem cell paradigm , C. Eyler, J. Heddleston, S. Rhinos, M. Hitomi, O. Guryanova, W. Flavahan, A. Hjelmeland, and J. Rich.
- ISBN: 978-1-61779-001-0
- Editorial: Humana
- Encuadernacion: Cartoné
- Páginas: 370
- Fecha Publicación: 25/01/2011
- Nº Volúmenes: 1
- Idioma: Inglés