Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful. The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels. Contributors are authoritative researchers who have produced important advances in the field. The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject. INDICE: Store-operated Orai channels: structure and functionMurali PrakriyaSTIM-Orai Interactions that Control the CRAC ChannelAparna Gudlur, Yubin Zhou and Patrick G. HoganStructure and Function of Endoplasmic Reticulum STIM Calcium SensorsPeter B. Stathopulos and Mitsuhiko IkuraOn the Stoichiometry of Resting and Activated CRAC ChannelsLiangyi Chen and Tao XuAlternative forms of the Store-operated Calcium Entry Mediators, STIM1 and Orai1James W. PutneyThe ARC Channel - An Endogenous Store-independent Orai ChannelJill L. Thompson, Olivier Mignen, and Trevor J. ShuttleworthContribution and Regulation of TRPC Channels in Store-Operated Ca2+ EntryKwong Tai Cheng, Hwei Ling Ong, Xibao Liu, and Indu S. AmbudkarMolecular Regulation of the Pore Component of CRAC Channels, Orai1Sonal Srikanth and Yousang GwackEmerging Roles for Native Orai Ca2+ Channels in Cardiovascular DiseaseBrian Ruhle and Mohamed TrebakThe Neglected CRAC Proteins: Orai2, Orai3 and STIM2Markus Hoth and Barbara A. Niemeyer
- ISBN: 978-0-12-407870-3
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 298
- Fecha Publicación: 24/09/2013
- Nº Volúmenes: 1
- Idioma: Inglés