The concept of specific receptors for drugs, hormones and transmitters lies at the very heart of biomedicine. This book is the first to consider the idea from its 19th century origins in the work of John Newport Langley and Paul Ehrlich, to its development of during the 20th century and its current impact on drug discovery in the 21st century. ÍNDICE: - Introduction - Paul Ehrlich and his Receptor Concept - The Development of the Concept of Drug Receptors in the Physiological Research of J. N.Langley - The Receptors and Scientific Pharmacology I: The Critics of the Receptor Idea and Alternative Theories of Drug Action, c. 1905-1935 - The Receptors and Scientific Pharmacology II: The Critics of the Receptor Idea and Alternative Research Strands: The Transmitter Theory, c. 1905-1935 - Quantitative Arguments for the Existence of Drug Receptors and the Development of the Receptor Occupancy Theory, c. 1910-1960 - The Dual Adrenaline Receptor Theory of Raymond P. Ahlquist (1914-1983) and its Application in Drug Development between - 1950 and 1970 - The Emergence of Molecular Pharmacology - Conclusions - Archival Sources - Bibliography
- ISBN: 978-0-230-55415-3
- Editorial: Palgrave Macmillan
- Encuadernacion: Cartoné
- Páginas: 256
- Fecha Publicación: 31/12/2008
- Nº Volúmenes: 1
- Idioma: Inglés