Peptide and Peptidomimetic Therapeutics: From Bench to Bedside

Peptide and Peptidomimetic Therapeutics: From Bench to Beside offers applied, evidence-based instruction on developing and applying peptide therapeutics in disease treatment, driving drug discovery, and improving patient care. Here, researchers, clinicians and students will find tools to harness the full power of peptides and peptidomimetics and improve bioavailability, stability, efficiency and selectivity of new therapeutics and their application in treatment plans. More than 20 leaders in the field share their approaches for identifying and advancing peptide and peptidomimetic therapeutics. Topics examined run from bench to bedside, beginning with fundamental peptide science, protein-protein interactions and peptide synthesis. Later chapters examine modes for peptide drug delivery, including cell penetration peptide and peptidomimetic delivery, as well as the targeting of specific disease types, peptide therapeutics as applied to infectious disease, cancer, metabolic disorders, neurodegenerative disorders, and skin disorders, and antiparasitic and immunosuppressive peptidomimetics. Helps researchers and clinicians harness the full of power of peptides and peptidomimetics in their daily work and drug discovery Features chapters running from bench to bedside?, providing a thorough grounding in fundamental peptide science, drug delivery methods, and targeting of specific disease types Features chapter contributions from international leaders in peptide science and drug development INDICE: History 1. Therapeutic peptides: historical perspectives and current development trends Basic science 2. Therapeutic peptidomimetics: targeting the undruggable space 3. Tailoring peptides and peptidomimetics for targeting protein-protein interactions 4. Advances in peptide synthesis 5. Stapled peptidomimetic therapeutics 6. Ring closing metathesis Drug discovery 7. The current state of backbone cyclic peptidomimetics and their application to drug discovery 8. Pharmacokinetics and pharmacodynamics of peptidomimetics 9. Formulations of peptides and peptidomimetics 10. Cell-penetrating peptides 11. Intracellular peptides as drug prototypes 12. Applications of computational three-dimensional structure prediction for antimicrobial peptides Therapeutic applications 13. Knottin peptidomimetics as therapeutics 14. Venom peptidomimetics as therapeutics 15. Therapeutic peptides targeting protein kinase: progress, challenges and future directions, featuring cancer and cardiovascular disease 16. Therapeutic peptidomimetics for infectious diseases 17. Antiparasitic therapeutic peptidomimetics 18. Peptides and antibiotic resistance 19. Antimicrobial peptides and the skin and gut microbiomes 20. Peptide and peptidomimetic based vaccines 21. Therapeutic peptidomimetics for cancer treatment 22. Immunomodulatory peptidomimetics for multiple sclerosis therapy - the story of glatiramer acetate (Copaxone) 23. Therapeutic peptidomimetics in metabolic diseases 24. Therapeutic peptidomimetics in anesthesiology 25. Cardiovascular-derived therapeutic peptidomimetics in cardiovascular disease 26. Non-cardiovascular-derived therapeutic peptidomimetics in cardiovascular disease Drug development 27. Clinical and preclinical data on therapeutic peptides 28. Therapeutic peptides: manufacturing and market 29. Future perspectives on peptide therapeutics

• ISBN: 978-0-12-820141-1
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 416
• Fecha Publicación: 01/08/2022
• Nº Volúmenes: 1
• Idioma: Inglés