The goal of this volume is to comprehensively cover a highly readable overview on our present knowledge of the role of Notch signalling for embryology and cancer, with a focus on new findings in molecular biology. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in cellular and molecular pathology to new concepts for prophylaxis andtreatment of cancer. Experts in the field as well as scientists and health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of this book to summarize essential up-to-date information for every clinician or scientist interested in the role of Notch signalling in embryology and cancer. We hope that this volume will be adopted as the standard text in this area of science and will stimulate new interest in the role of Notchsignalling for embryology and cancer. We further hope that this compendium will serve as both a source for current researchers and a guide to stimulate andassist those in related disciplines to enter this exciting field of research.Comprehensive in scope, covers an overview on our present knowledge of the role of Notch signalling for embryology and cancer, with a focus on new findingsin molecular biology. Topics are discussed in-depth by leading researchers and clinicians range from the newest findings in cellular and molecular pathology to new concepts for prophylaxis and treatment of cancer. Brings the diverse scientific and clinical fields together in one definitive and up-to-date volume. INDICE: The Molecular Basis of Notch Signaling: A Brief Overview. The Roleof Adams in Notch Signaling. Metabolism and Transportation Pathways of GDP?Fucose that are Required for the O ?Fucosylation of Notch. Notch Signaling and the Generation of Cell Diversity in Drosophila Neuroblast Lineages. NEPRO: A Novel Notch Effector for Maintenance of Neural Progenitor Cells in the Neocortex. Notch Signaling and Development of the Hematopoietic System. Notch Signalingin Lung Development and Disease. The Role of Notch Signaling in Kidney Development and Disease. Notch Signaling and the Developing Skeleton. Notch Signaling and the Developing Skin Epidermis. Notch Signaling and the Developing Hair Follicle. Notch Signaling and the Developing Inner Ear. Notch Signaling in Cancer Stem Cells. Notch Signaling Pathway and Cancer Metastasis. Notch, Apoptosisand Cancer. Ligand?Dependent Notch Signaling in Vascular Formation. Notch andthe P53 Clan of Transcription Factors. Notch Signaling and Breast Cancer. Notch Signaling and Malignant Melanoma. Notch?Signaling and Nonmelanoma Skin Cancer: An Ancient Friend, Revisited. Notch Signaling and Intestinal Cancer. NotchSignaling and Brain Tumors. Notch Inhibition as a Promising New Approach to Cancer Therapy.
- ISBN: 978-1-4614-0898-7
- Editorial: Springer New York
- Encuadernacion: Cartoné
- Páginas: 322
- Fecha Publicación: 01/10/2011
- Nº Volúmenes: 1
- Idioma: Inglés