INDICE: Introduction. 1 Getting Started. The Technique. Instrumentation. CWSystems. FT Systems. Origin of the Chemical Shift. Origin of 'Splitting'. Integration. 2 Preparing the Sample. How much sample do I need? Solvent Selection. Deutero Chloroform (CDCl3). Deutero Dimethyl Sulfoxide (DMSO). Deutero Methanol (CD3OD). Deutero water (D2O). Deutero Benzene (C6D6). Carbon Tetrachloride(CCl4). Trifluoroacetic acid (CF3COOH). Using Mixed Solvents. Spectrum Referencing (Proton NMR). Sample Preparation. Filtration. 3 Spectrum Acquisition. Number of Transients. Number of Points. Spectral Width. Acquisition Time. Pulse Width. Relaxation Delay. Number of Increments. Shimming. Tuning and Matching. Frequency Lock. Run unlocked. Internal lock. External lock. To Spin or Not to Spin. 4 Processing. Introduction. Zero-Filling and Linear Prediction. Apodization. Fourier Transformation. Phase Correction. Baseline Correction. Integration. Referencing. Peak Picking. 5 Interpreting Your Spectrum. Common Solvents and Impurities. Group 1 Exchangeables and Aldehydes. Group 2 Aromatic and Heterocyclic Protons. Monosubstituted Benzene Rings. Multisubstituted Benzene Rings.Heterocyclic Ring Systems (Unsaturated) and polycyclic aromatic systems. Group 3 Double and Triple Bonds. Group 4 Alkyl Protons. 6 Delving Deeper. Chiral centres. Enantiotopic and Diastereotopic Protons. Molecular Anisotropy. Accidental Equivalence. Restricted Rotation. Heteronuclear Coupling. Coupling betweenprotons and 13C. Coupling between protons and 19F. Coupling between protons and 31P. Coupling between 1H and other heteroatoms. Cyclic Compounds and the Karplus Curve. Salts, Free Bases and Zwitterions. 7 Further Elucidation Techniques Part 1. Chemical Techniques. Deuteration. Basification and Acidification. Changing Solvents. Trifluoroacetylation. Lanthanide Shift Reagents. Chiral Resolving Agents. 8 Further Elucidation Techniques Part 2. Instrumental Techniques. Spin-Decoupling (homonuclear, 1-D). COSY (Correlated Spectroscopy). TOCSY (Total Correlation Spectroscopy) 1&2-D. The Nuclear Overhauser Effect (NOE) and Associated Techniques. 9 Carbon-13 NMR Spectroscopy. General Principles and 1-D 13C. 2-D Proton-Carbon (Single Bond) Correlated Spectroscopy. 2-D Proton-Carbon (Multiple Bond) Correlated Spectroscopy. Piecing It All Together. Choosingthe Right Tool. 10 Some of the Other Tools. HPLC-NMR. Flow NMR. Solvent Suppression. MAS (Magic Angle Spinning) NMR. Other 2-D Techniques. INADEQUATE. J-Resolved. DOSY. 3-D Techniques. 11 Some of the Other Nuclei. 12 Quantification. Introduction. Relative Quantification. Absolute Quantification. Internal Standards. External Standards. Electronic Reference (ERETIC). QUANTAS. Things to Watch Out For. Conclusion. 13 Safety. Magnetic Field
- ISBN: 978-0-470-71092-0
- Editorial: John Wiley & Sons
- Encuadernacion: Cartoné
- Páginas: 216
- Fecha Publicación: 01/01/2011
- Nº Volúmenes: 1
- Idioma: Inglés