Biochemistry of Lipids, Lipoproteins and Membranes, Seventh Edition serves as a comprehensive, general reference book for scientists and students studying lipids, lipoproteins and membranes. Here, across 19 chapters, leaders in the field summarize fundamental concepts, recent research developments, data analysis, and implications for human disease and intervention. Topics discussed include lipid biology in both prokaryotes and eukaryotes, fatty acid synthesis, desaturation and elongation, and pathways leading to synthesis of complex phospholipids, sphingolipids and their structural variants. Chapters also examine how bioactive lipids are involved in cell signaling, with an emphasis on disease implications and pathological consequences. As the field advances, each chapter in this new edition has been fully revised to address emerging topics, with all-new coverage of lipid droplets and their role as regulatory organelles for energy homeostasis, as well as their relationship to obesity, liver disease and diabetes. Evolving research in fatty acid handling and storage in eukaryotes is also discussed in-depth, with new sections addressing fatty acid uptake, activation and lipolysis. Fully revised to cover new and emerging topics Provides an important bridge between broad-based biochemistry research and application Presents key concepts that are supported by figures and models to improve understanding Includes references from current literature in each chapter to facilitate in-depth study INDICE: 1. Functional roles of lipids in biological membranesMikhail Bogdanov and William Dowhan2. Methods of lipid analysisBebiana C. Sousa, Michael J.O. Wakelam and Andrea F. Lopez-Clavijo3. Fatty acid and phospholipid biosynthesis in prokaryotesJessica M. Gullett and Charles O. Rock4. Lipid metabolism in plantsKatherine M. Schmid5. Fatty acid handling in mammalian cellsRichard Lehner and Ariel D. Quiroga6. Fatty acid desaturation and elongation in mammalsLucas M. O'Neill, Makoto Miyazaki, Laura M. Bond, Sarah A. Lewis, Fang Ding, Zhaojin Liu and James M. Ntambi7. Phospholipid synthesis in mammalian cellsNeale Ridgway8. Phospholipid catabolismDakai Zhang and Guangwei Du9. SphingolipidsAnthony H. Futerman10. Cholesterol synthesisAndrew J. Brown, Hudson W. Coates and Laura J. Sharpe11. Structure and function of lipid dropletsHongyuan Yang and Jun Liu12. Bile acid metabolismJennifer K. Truong and Paul A. Dawson13. Lipid modification of proteinsMarilyn D. Resh14. Inter- and intra-membrane lipid transportVesa M. Olkkonen and Elina Ikonen15. High-density lipoproteins metabolism and protective rolesValentin Blanchard and Gordon A. Francis16. Assembly and secretion of triglyceride-rich lipoproteinsEric A. Fisher and Roger S. McLeod17. Lipoprotein(a)Michael B. Boffa and Marlys L. Koschinsky18. Lipoprotein receptorsKristina Kuhbandner, Joachim Herz and Theresa Pohlkamp19. AtherosclerosisMurray W. Huff and Katey J. Rayner20. Diabetic dyslipidaemiaKhosrow Adeli, Changting Xiao, Victoria Higgins, Jennifer Taher, Sarah Farr and Gary F. Lewis
- ISBN: 978-0-12-824048-9
- Editorial: Elsevier Science
- Encuadernacion: Rústica
- Páginas: 736
- Fecha Publicación: 23/08/2021
- Nº Volúmenes: 1
- Idioma: Inglés