Proteins lie at the heart of almost all biological processes and have an incredibly wide range of activities. Central to the function of all proteins is their ability to adopt, stably or sometimes transiently, structures that allow for interaction with other molecules. Since model structures may also take advantage of new function prediction algorithms, the first part of the book deals with the various ways in which protein structures may be predicted or inferred, including specific treatment of membrane and intrinsically disordered proteins. A detailed consideration of current structure-based function prediction methodologies forms the second part of this book, which concludes with two chapters, focusing specifically on case studies, designed to illustrate the real-world application of these methods. With bang up-to-date texts from world experts, and abundant links to publicly available resources, this book will be invaluable to anyone who studies proteins. Comprehensively covers all recent developments in structure-based function prediction of proteins Contains abundant links to publicly available resources Genuinely world class roster of authors Includes full coverage of techniques to generate and infer model protein structures Separate chapters of case studies illustrating current practice in structure-based function prediction INDICE: Part 1: Generating and inferring structures. 1 Ab initio protein structure prediction. 2 Fold Recognition. 3 Comparative protein structure modelling. 4 Membrane protein structure prediction. 5 Bioinformatics approaches to the structure and function of intrinsically disordered proteins. Part 2: From structures to functions. 6 Function diversity within folds and superfamilies. 7 Predicting protein function from surface properties. 8 3D Motifs. 9 Protein dynamics: from structure to function. 10 Integrated servers for structure-informed function prediction. 11 Case studies: Function predictions of structural genomics results. 12. Prediction of protein function from theoretical models. Index.
- ISBN: 978-1-4020-9057-8
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 328
- Fecha Publicación: 01/02/2009
- Nº Volúmenes: 1
- Idioma: Inglés