Scientific Principles of Adipose Stem Cells

Scientific Principles of Adipose Stem Cells provides readers with in depth and expert knowledge on adipose stem cells in regards to developmental biologic origins, foundational research on ASC signaling mechanisms and immunomodulatory properties and clinical insights into applications in regenerative medicine. Written for scientists and clinicians who are broadly familiar with stem cells and basic cell biology principles and are seeking advanced information on adipose stem cells. Topics covered include basic adipose stem cell developmental biology (maturation process during embryogenesis) and mechanisms of regulating self-renewal and activation in the stem cell niche, important methods for isolation and characterizing ASCs, as well as known data any impact of human demographics (age, sex, BMI) on ASC phenotype. A section devoted to ASC biology, additional sections are devoted to ASCs for stem cell therapy and regenerative medicine, as well as ASCs in tissue engineering applications. Given the broad applications for which ASCs are used, as well as the interest in basic ASC science, Scientific Principles of Adipose Stem Cells transcends an audience of plastic surgeons and provides valuable and expert knowledge in developmental and cell biology appealing to basic scientists in a variety of fields. Information on cell manufacturing and commercialization, FDA regulations and ASC exosomes which appeal to those working in industry and applications of ASCs in cutting edge tissue engineering applications such as microphysiologic systems and/or bioreactors, are also included. These new technologies have important applications in drug discovery and for studying genetically modified ASCs. Coverage of basic adipose stem cell developmental biology (maturation process during embryogenesis) and mechanisms of regulating self-renewal and activation in the stem cell nicheIncludes important methods for isolation and characterizing ASCs, as well as known data any impact of human demographics (age, sex, BMI) on ASC phenotypeAn entire section dedicated to ASC biology, additional sections will be devoted to ASCs for stem cell therapy and regenerative medicine, as well as ASCs in tissue engineering applications INDICE: Part 1. Introduction and Front Matter 1. Historical Review of Adipose Stem Cells: Discovery and Important Concepts Part 2. Basic Biology of Adipose Stem Cells 2. The Developmental Origins of Adipose Tissue 3. Establishing the Adipose Stem Cell Identity: Characterization Assays and Functional Properties 4. Maintenance of Adipose Stem Cells in the Stem Cell Niche: Molecular Mechanisms Regulating Self-Renewal and Activation 5. Adipose Stem Cells in Beige and Brown Fat 6. Adipose Stem Cells and Aging 7. Adipose Tissue and Stem Cell Secretomes 8. Adipose MUSE Cell Expression of Pluripotency Genes and Plasticity 9. Adipose Mesenchymal Stem Cell Homing Mechanisms after Injury 10. Bioreactors and MPS systems for adipose-based pharmacologic screening  Part 3. Adipose Cell Therapy and Regenerative Medicine 11. Animal Models in Adipose Stem Cell Research 12. Adipose Stem Cells and Donor Demographics: Impact of Anatomic Location, Donor Sex, Race, BMI and Health 13. Adipose Stem Cell Immunomodulatory Properties 14. Clinical Experience with Adipose Tissue enriched with Adipose Stem Cells 15. Adipose Stem Cells for Wound Healing and Fibrosis 16. Oncologic Safety of Adipose Cell Therapy 17. FDA Regulations on Adipose Cell Use in Clinical Trials and Clinical Translation Part 4. Engineering with Adipose Stem Cell 18. Biomaterial Control of Adipose Stem Cell Differentiation 19. Methods for Genetically Modifying Adipose Stem Cells 20. Adipose Stem Cells for Bone and Cartilage Engineering 21. Hematopoietic Potential of Adipose Stem Cells 22. Adipose Stem Cells for Vascular Engineering 23. Adipose Stem Cells for Peripheral Nerve Engineering Part 5. Conclusions and Back Matter 24. Future Research in Adipose Stem Cells and Regenerative Medicine

• ISBN: 978-0-12-819376-1
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 350
• Fecha Publicación: 03/11/2020
• Nº Volúmenes: 1
• Idioma: Inglés