INDICE: Preliminary Chapter Outline (Table of Contents) Part I: Introduction: Complexity of the MMP family of Proteins: Substrates and Specificity. Zena Werb– The role of the extracellular matrix and its degradation in cancer progression Irit Sagi– Degradation of Superstructured Substrates by MMPs Dylan Edwards– MMPs in cancer: progression and protection Chris Overall – Looking towards the future of MMP research Part II: Structure Function of MMPs and TIMPS F. Xavier Gomez Ruth & Wolfram Bode– Structural Characterization of MMPs Claudio Luchinat– NMR Studies of MMPs Rama Khoka– The Endogenous Inhibitors of the MMPs (TIMPS) Part IIa: Membrane Bound MMPs Motaharu Seiki– MT1 MMP Jian Cao– The role of MT1–MMP in early cancer dissemination Part III: Small Molecule Inhibitors: Past, Present and Future Vincent Dive – History of small molecule development and future directions Achim Kruger – Difficulties of targeting the MMPs in the clinic Stephen Prior – Using Swarm intelligence to determine the structure of MMP– Inhibitor complexes Stanley Zucker – Targetting MMPs: Where do we go from here? Part IV: Towards the Clinic Barbara Fingleton– MMP10 Healing the Mucosa Sharon Stack– Protease in Ovarian Cancer/ Model Systems Michal Schwartz– Spinal Chord Injury and MMPs Alex Strongin– Nerve Injury, Neuropathic Pain and MMPs
- ISBN: 978-1-118-77232-4
- Editorial: Wiley–Blackwell
- Encuadernacion: Cartoné
- Páginas: 376
- Fecha Publicación: 30/06/2014
- Nº Volúmenes: 1
- Idioma: Inglés