Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification, which has broad potential for improving diagnosis, prognosis, prediction and risk assessment. This volume offers a unique evaluation of signature differences of childhood, sex-specific and race-specific cancers, broadly illuminating the scope of epigenetic biomarkers in clinical environments. Chapters detail the major epigenetic processes in humans consisting of DNA methylation, histone modifications and microRNAs (miRNAs) involved in the initiation, progression and metastasis of tumors. Also delineated are recent technologies, such as next generation sequencing that are used to identify epigenetic profiles (primarily methylation analysis) in samples (normal, benign and cancerous) and which are highly important to the analysis of epigenetic outcomes. Offers broad coverage that is applicable to audiences in various area of cancer research - population studies, diagnostics, prognosis, prediction, therapy, risk, etc.Provides critical review analysis of the topics that will clarify and delineate the potential roles of epigenetic signatures in cancer managementCovers basic, as well as, clinical areas of epigenetic mechanisms in tumorigenesisFeatures contributions by leading experts in the fieldProvides comprehensive coverage of current epigenetic signatures involved in the etiology of various cancers and miRNAs INDICE: Section I: Overview 1. Cancer Epigenetics Section II: Epigenetics of childhood cancers 2. Epigenetic changes in pediatric leukemia 3. Epigenetic mechanisms involved in pediatric solid tumors 4. Role of miRNAs in childhood cancers 5. Comparative assessments of epigenetic signatures in tumor types (solid versus liquid) of childhood cancers Section III: Epigenetic influence on female reproductive cancers 6. Epigenetics of breast cancer 7. Epigenetic modulations in ovarian cancer 8. The epigenetic origins of cervical cancer 9. Epigenetic aberrations and uterine cancer Section IV: Epigenetic aberrations and male reproductive cancers 10. Changes in the epigenetic landscape of prostate cancer 11. Role of epigenetics in testicular cancer Section V: Epigenetic basis of tumor development across populations and race-based epigenetic differences 12. Impact of race/ethnicity on the epigenetics of lung cancer 13. Epigenetic health disparities and colon cancer 14. Ethnic epigenetic differences in the onset of pancreatic cancer Section VI. Epigenetic epidemiology of cancer 15. Epigenetic epidemiology for cancer risk 16. Epigenetic biomarkers in cancer epidemiology Section VII: Epigenomic methods, biomarkers and cancer management 17. Cancer epigenomics - methylomes, histone maps and micronomes 18. Epigenetic signatures in the diagnosis and prognosis of cancer 19. Predictive value of epigenetic signatures 20. Epigenetic biomarkers and racial differences in cancer Section VIII: Challenges and Future Directions 21. Future Challenges and Prospects for the role of epigenetic mechanism in cancer management
- ISBN: 978-0-12-809552-2
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 450
- Fecha Publicación: 01/10/2017
- Nº Volúmenes: 1
- Idioma: Inglés