Handbook of Innovations in CNS Regenerative Medicine

The complexity of Central Nervous System (CNS) disorders demands the development of innovative therapies. Areas such as cell transplantation approaches, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies are key in regenerative medicine approaches that target injury and disease within the CNS. In the last decade, we have witnessed the emergence of different approaches within these fields that will probably pave the way for the emergence of innovative therapies that can target CNS injury and disease in the future. However, when developing such complex and combined strategies for therapeutic use one has to be aware of both regulatory and ethical issues, including the procedures and appropriate paths to follow to adequately take a concept from the bench, to a clinical product or methodology to the bedside. Handbook on Recent Trends in Central Nervous System Regenerative Medicine provides a comprehensive overview of the CNS regenerative medicine field. The book describes the basic biology and anatomy of the CNS, and how injury and disease affect its balance and the limitations of the present therapies used in the clinics. It also introduces the recent trends in different fields of CNS regenerative medicine including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies. Finally, the book presents successful cases of translation of basic research to first-in-human trials, and the steps needed to follow this path. Describe the basic biology and anatomy of the CNS, and how injury and disease affect its balanceDiscusses the limitations of the present therapies used in the clinicsIntroduces the recent trends in different fields of CNS regenerative medicine including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologiesPresents successful cases of translation of basic research to first-in-human trials, and the steps needed to follow this path INDICE: 1. Insights on Nervous System Biology and Anatomy2. Introduction to Neurodegenerative Diseases3. Introduction to Trauma in CNS4. Impact of Neuro-inflammation in Injury and Disease in the CNS5. Current Clinical Approaches in Neurodegenerative Diseases6. Neuroprotection in the Injured Spinal Cord7. Immunomodelatory Approaches for Tackling Neuro-Inflammation8. Role of Fetal and Adult Tissues in CNS Regenerative Medicine9. Adult Stem Cells Therapeutic Potential for Injured CNS10. iPSCs: An Essential Toolkit for Repair and Regeneration of the CNS?11. Biomaterial-Based Systems as Biomimetic Agents int he Repair of the CNS12. Tissue Engineering and Regenerative Medicine in CNS Repair13. New Trends Drug Delivery in CNS Regeneration14. Gene Therapy Approaches in CNS Regenerative Medicine15. Gene Editing and CNS Regeneration16. Molecular Therapies in Neurodegeneration and Injury17. Deep Brain Stimulation and Parkinson's Disease18. Brain-Spinal Cord Interfaces19. Electroceuticals20. Secretome of Cells and Its Role in Neuroregeneration21. 3D Organoids and Bioreactors22. Microfluidics and Lab-on-a-Chip23. Translational Research: From Proof of Concept to Clinical Trials24. Advanced Therapies Medicinal Products25. Animal Models of CNS Disorders26. Bioethics in Translation Research and Clinical Trials

• ISBN: 978-0-12-818084-6
• Editorial: Elsevier
• Encuadernacion: Rústica
• Páginas: 500
• Fecha Publicación: 03/02/2020
• Nº Volúmenes: 1
• Idioma: Inglés