“The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. It is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected. Future studies of ADARs no doubt will provideus with additional surprises and new insights into the modulation of biological processes by the ADAR family of proteins.”. The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they fact to affect gene expression and product function. It is becomingincreasingly apparent that ADARs may function not only as enzymes that deaminate adenosine in RNA substrates with double-stranded character, but also as RNA binding proteins independent of their catalytic property. Future studies of ADARs no doubt will provide us with additional surprises and new insights intothe modulation of biological processes by the ADAR family of proteins
- ISBN: 978-3-642-22800-1
- Editorial: Springer Berlin Heidelberg
- Encuadernacion: Cartoné
- Páginas: 250
- Fecha Publicación: 31/08/2011
- Nº Volúmenes: 1
- Idioma: Inglés