Mitochondria in Neurological Diseases highlights various therapeutic approaches targeting mitochondria in neurological conditions. Focused on diverse neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, depression, and Amyotrophic lateral sclerosis, topics span basic mitochondrial physiology to mitochondrial dynamics and to the altered states of the nervous system. This book is appropriate for anyone interested in learning more about the physiological and pathophysiological functions of mitochondria in the nervous system. Provides up-to-date information on role of mitochondria in nervous system for graduate students and researchers Presents chapters on energy substrate utilization, calcium handling, mitochondria-organelle communication, and cell signaling Discusses recent techniques in understanding mitochondrial functions in the nervous system Emphasizes the role of altered mitochondrial functions in various neurological conditions and their potential treatment strategies for targeting mitochondria Includes chapter references (key articles, books, protocols) for additional detailed study INDICE: 1. Mitochondria in functions of nervous system2. Mitochondrial calcium homeostasis in synaptic functions3. Mitochondrial regulation of neuronal plasticity4. Communication between mitochondria and other organelles5. Axoplasmic mitochondrial transport: From Molecules to Mechanisms6. Yeast as a model for studying human neurodegenerative disorders7. Sex differences in mitochondrial metabolism8. Mitochondrial oxidative stress and neurodegeneration9. Mitochondrial metabolism in neurological disorders10. Altered mitochondrial signalling in neurodegenerative conditions11. Mitochondrial DNA, base excision repair and neurodegeneration12. microRNAs regulating mitochondrial functions in brain13. Mitochondrial Chaperones in Neurodegenerative Disorders14. Proteomic profiling of mitochondria in neurodegenerative conditions15. Association of mitochondrial genetic variants with neurological disorders16. Mitochondrial dynamics in diseases of nervous system17. Mitochondrial thiol dioxygenases in diseases of the nervous system18. Mitophagy in Neurodegenerative Diseases19. Mitochondria and neuroinflammation20. Mitochondrial functions in Alzheimer's Disease21. Mitochondria in Amyotrophic lateral sclerosis22. Pathways involved in mitochondrial dysfunctions in Huntington's Disease23. Mitochondrial cascades in Parkinson's Disease24. Mitochondrial dysfunctions in Psychiatric Disorders25. Mitochondria in Brain Injury26. Mitochondrial epigenetics in neurodegeneration27. Transmitochondrial Cybrids: A cellular model to study mutant mitochondria28. Targeting mitochondria in neurodegenerative disorders29. Mitochondrial modulators in neuroprotection30. Polyphenols and mitochondria in neurodegneration31. Transplantation of mitochondria in neurodegenerative disorders
- ISBN: 978-0-12-821731-3
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 500
- Fecha Publicación: 01/09/2022
- Nº Volúmenes: 1
- Idioma: Inglés