At last: a comprehensive treaty on one of the most successful drugs ever. Oneof the leading figures in Aspirin-related research presents a comprehensive treaty on the history, pharmacology and the clinical applications of this amazing drug. INDICE: TABLE OF CONTENTS 1. GENERAL ASPECTS 1.1 HISTORY 1.1.1 WILLOW BARKAND LEAVES AS ANTIPYRETIC, ANTI-INFLAMMATORY ANALGESICS 1.1.2 SALICYLATES AS THE ACTIVE INGREDIENT OF WILLOW BARK AND OTHER NATURAL SOURCES 1.1.3 SYNTHESISOF ACETYLSALICYLIC ACID AND FIRST CLINICAL STUDIES 1.1.4 MODE OF ASPIRIN ACTION 1.1.5 ANTI-INFLAMMATORY/ANALGESIC ACTIONS OF ASPIRIN 1.1.6 ASPIRIN IN THE CARDIOVASCULAR SYSTEM 1.1.7 CURRENT RESEARCH TOPICS 1.2 CHEMISTRY 1.2.1 STRUCTURES AND CHEMICAL PROPERTIES OF SALICYLATES 1.2.2 DETERMINATION OF SALICYLATES 2. PHARMACOLOGY 2.1 PHARMACOKINETICS 2.1.1 ABSORPTION AND DISTRIBUTION 2.1.2 BIOTRANSFORMATION AND EXCRETION 2.2 CELLULAR MODES OF ACTION 2.2.1 INHIBITION OF CYCLOOXYGENASES 2.2.2 COX-INDEPENDENT ACTIONS ON CELL FUNCTION 2.2.3 ENERGY METABOLISM 2.3 ACTIONS ON ORGANS AND TISSUES 2.3.1 HEMOSTASIS AND THROMBOSIS 2.3.2 INFLAMMATION, PAIN AND FEVER 2.3.3 ASPIRIN AND MALIGNANCIES 3. TOXICITY AND DRUG SAFETY 3.1 SYSTEMIC SIDE-EFFECTS 3.1.1 ACUTE AND CHRONIC TOXICITY 3.1.2 BLEEDING DISORDERS 3.1.3 SAFETY PHARMACOLOGY IN PARTICULAR LIFE SITUATIONS 3.2 ORGAN TOXICITY 3.2.1 GASTROINTESTINAL (GI) TRACT 3.2.2 KIDNEY 3.2.3 LIVER 3.2.4 AUDIOVESTIBULAR SYSTEM 3.3 NON-DOSE-RELATED (PSEUDO)ALLERGIC ACTIONS OF ASPIRIN 3.3.1 ASPIRIN HYPERSENSITIVITY (WIDAL'S SYNDROME) 3.3.2 URTICARIA/ANGIOEDEMA, STEVENS-JOHNSON- AND LYELL-SYNDROME 3.3.3 REYE SYNDROME 4. CLINICAL APPLICATIONS OF ASPIRIN 4.1 THROMBOEMBOLIC DISEASES 4.1.1 CORONARY VASCULAR DISEASE 4.1.2 CEREBROVASCULAR DISEASES 4.1.3 PERIPHERAL ARTERIAL DISEASE (PAD) 4.1.4 VENOUS THROMBOSIS 4.1.5 PREECLAMPSIA 4.1.6 ASPIRIN "RESISTANCE" 4.2 PAIN, FEVER AND INFLAMMATORY DISEASES 4.2.1 ASPIRIN AS AN ANTIPYRETIC ANALGESIC 4.2.2 ARTHRITIS AND RHEUMATISM 4.2.3 KAWASAKI DISEASE 4.3 FURTHER CLINICAL INDICATIONS 4.3.1 COLORECTAL CANCER 4.3.2 ALZHEIMER DISEASE ABBREVIATIONS (NO ACRONYMS FOR CLINICAL STUDIES) ACRONYMS FOR CLINICAL STUDIES INDEX TERMS (PRELIMINARY)
- ISBN: 978-3-527-32109-4
- Editorial: Wiley-VCH
- Encuadernacion: Cartoné
- Páginas: 390
- Fecha Publicación: 12/11/2008
- Nº Volúmenes: 1
- Idioma: Inglés