Peptide folding, misfolding, and nonfolding

INDICE: A. Introduction 1. Why are we interested in the unfolded peptides and proteins? Vladimir Uversky and Keith Dunker B. Conformational analysis of unfolded states 2. Exploring the landscape of small peptides with MD simulations Gerhard Stock, Abhinav Jain, Laura Riccardi, and Phuong H. Nguyen 3. Local backbone preferences and nearest neighbor effects in the unfolded and native states Joe DeBartolo, Abhishek Jha, Karl F. Freed, and Tobin R. Sosnick 4. Short-distance FRET applied to the polypeptide chain Maik Jacob and Werner Nau 5. Solvation and electrostatics as determinants of conformational propensities in unfolded peptides and proteins Franc Avbelji 6. Experimental and ComputationalStudies of Polyproline II Propensity W. Austin Elam, Travis P. Schrank, Vincent J. Hilser 7. Mapping conformational dynamics in unfolded polypeptide chainsusing short model peptides by NMR spectroscopy Daniel Mathieu, Karin Rybka, Jürgen Graf and Harald Schwalbe 8. Secondary Structure and Dynamics of a Familyof Disordered Proteins Pranesh Narayanaswami and Gary Daughdrill C. Disordered Peptides and Molecular Recognition 9. Binding promiscuity of unfolded peptides Christopher J. Oldfield, Bin Xue, A. Keith Dunker, and Vladimir N. Uversky 10. Intrinsic flexibility of nucleic acid chaperone proteins from pathogenic RNA viruses Roland Ivanyi-Nagy, Zuzanna Makowska, and Jean-Luc Darlix D. Aggregation of disordered peptides 11. Self-Assembling Alanine-Rich Peptides of Biomedical and Biotechnological Relevance Thomas Measey and Reinhard Schweitzer-Stenner 12. Structural Elements Regulating Interactions in the Early Stages of Fibrillogenesis: A Human Calcitonin Model System Rosa Maria Vitale, Giuseppina Andreotti, Pietro Amodeo, and Andrea Motta 13. Solution NMR Studies of A² Monomers and Oligomers Chunyu Wang 14. Thermodynamic and Kinetic Models for Aggregation of Intrinsically Disordered Proteins Scott L. Crick and Rohit V. Pappu 15. Modifiers of protein aggregation from non-specific to specific interactionsMichal Levy-Sakin, Roni Scherzer-Attali and Ehud Gazit 16. Computational Studies of Folding and Assembly of Amyloidogenic Proteins J. Srinivasa Rao, Brigita Urbanc and Louis Cruz

• ISBN: 978-0-470-59169-7
• Editorial: John Wiley & Sons
• Encuadernacion: Cartoné
• Páginas: 576
• Fecha Publicación: 15/03/2012
• Nº Volúmenes: 1
• Idioma: Inglés