Mutagenicity: Assays and Applications

Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation. Presents an up-to-date and in-depth review of the current state of mutagenesis researchDraws upon the combined experience and expertise of an international group of highly respected editors and chapter authorsProvides an introduction to the concept of mutagenesis with particular consideration given to novel chemicals and materials INDICE: 1. Mutagenesis and health problems2. Molecular mechanisms of mutagenesis3. Bacterial mutation assays4. Gene mutation assays in cultured mammalian cells5. Chromosomal aberration test6. In vivo cytogenetic assay7. Mutagenicity testing in environmental pollution control8. Mutagens in food and water9. Emerging methods for the identification of mutagens10. Guidelines and registration of the new compounds or drug like molecules11. Mutagenicity testing, regulatory guidelines and current needs

• ISBN: 978-0-12-809252-1
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 256
• Fecha Publicación: 01/10/2017
• Nº Volúmenes: 1
• Idioma: Inglés