Emerging Nanotechnologies in Immunology: The Design, Applications and Toxicology of Nanopharmaceuticals and Nanovaccines

The scientific development of manufactured nanomaterials for drug delivery is increasing rapidly. One of the most prominent applications is topical drug delivery, where cutaneous, ocular and nasal exposure becomes even more relevant. These targets are the first barrier that nanoparticles encounter when in contact with the human body. This book aims to deliver a systematic and comprehensive review of data concerning the nature of interaction and nano-related risks between the nanopharmaceuticals currently in the pipeline of S&T development for skin, ocular and nasal drug delivery, including absorption, toxicity, and the ability to distribute after systemic exposure. The contributors address a representative set of the broad spectrum of nanopharmaceutics presently being used, including cationic lipid nanoparticles, polymeric PLGA, PLA nanoparticles, biomacromolecules-based nanoparticles, and other scaffolds tissue-engineered skin substitutes. Regulation and risk is also covered, since the safety of these nanopharmaceuticals still represents a barrier to their wide innovative use. Provides the reader with a thorough knowledge of the safety aspects of nanopharmaceuticals currently under research Focus on the characterization and quantification of nanopharmaceutics to allow readers to understand the correlation between the nature of the materials and their potential nanotoxicological effectsIncludes a thorough overview of the legal and regulatory aspects, including discussion of the ethical issues related to the R&D of nanopharmaceuticals INDICE: 1. Nanopharmaceutics in immunology: what's new in research? Ranjita Shegokar, Ana Rita Fernandes and Eliana Souto 2. Skin delivery of antimicrobial peptides Monika Schaefer-Korting and Jens Rolff 3. Skin penetration of nanoparticles Shohreh Nafisi and Howard I. Maibach 4. Regulatory and risk assessment perspective for Core-Multishell Nanocarriers: A novel excipient on its way towards marketing authorization Sam D. More, Margret More, Florian Paulus, Emanuel Fleige amd Marcin Libera 5. Anti-inflammatory drugs: Pharmaceutical Nanotechnology approach Andjelka B. Kovacevic, Sergio M.C.Silva and Slavomira Doktorovova 6. New strategies for the treatment of auto-immune diseases using nanotechnologies Amelia M. Silva, Joao R. Siopa, Carlos Martins-Gomes, Maria C. Teixeira, Dario J. Santos, Maria dos Anjos Pires and Tatiana Andreani 7. Nanopharmaceutics Applications in Inhaler Systems Aysu Yurdasiper, Mesut Arici and Mine Ozyazici 8. Immunomodulatory Effects of Curcumin in infectious and non-infectious diseases Ranjita Shegokar 9. Advances in Antibiotic Nanotherapy: Overcoming Antimicrobial Resistance Teixeira, M.C., Sanchez-Lopez, E., Espina, M., Calpena, A.C., Silva, A.M., Veiga, F.J., Garcia, M. L., Souto, E.B.

• ISBN: 978-0-323-40016-9
• Editorial: Elsevier
• Encuadernacion: Cartoné
• Páginas: 300
• Fecha Publicación: 01/05/2018
• Nº Volúmenes: 1
• Idioma: Inglés