This monograph addresses, in a systematic and pedagogical manner, the mathematical methods and the algorithms required to deal with the molecularly based problems of bioinformatics. The book will be useful to students, research scientists and practitioners of bioinformatics and related fields, especially thosewho are interested in the underlying mathematical methods and theory. Among the methods presented in the book, prominent attention is given to pair-wise and multiple sequence alignment algorithms, stochastic models of mutations, modulus structure theory and protein configuration analysis. Strong links to the molecular structures of proteins, DNA and other biomolecules and their analysesare developed. In particular, for proteins an in-depth exposition of secondary structure predicition methods should be a valuable tool in both molecular biology and in applications to rational drug design. Clearly explains the mathematical concepts behind bioinformatics. Makes direct connections to biomolecular structures such as proteins, DNA and RNA. INDICE: Outline.- Part I: Mutations and alignments.- Introduction.- Stochastic models of mutations and structure analysis.- Modulus structure theory.- Super pairwise alignment.- Multiple sequence alignment.- Network structures of multiple sequences induced by mutation.- Alignment space.- Part II: Protein configuration analysis.- Background information concerning the properties of proteins.- Informational and statistical iterative analysis of protein secondary structure prediction.- 3D structure analysis of the protein backbone and side chains.- Alignment of primary and 3D structures of proteins.- Depth analysis of protein spatial structure.- Analysis of the morphological features of protein spatial structure.- Semantic analysis for protein primary structure.
- ISBN: 978-3-540-74890-8
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 475
- Fecha Publicación: 01/02/2008
- Nº Volúmenes: 1
- Idioma: Inglés