Pharmaceutical process chemistry

Covering the whole area of process chemistry in the pharmaceutical industry, this monograph provides the essential knowledge on the basic chemistry needed for future development and key industrial techniques, as well as morphology, engineering and regulatory compliances. Application-oriented and well structured, the authors include recent examples of excellent industrial production of active pharmaceutical ingredients INDICE: PART 1: INTRODUCTORY REMARKS From Milligrams to Tons: The Importance of Synthesis & Process Research in the Development of New Drugs PART 2: FUTURE APPLICATIONS Design of Dynamic Salt Catalysts Based on Acid-Base Combination Chemistry Asymmetric Oxidation with Hydrogen Peroxide, an Effective and Versatile Oxidant New Methods for the Functionalization of Aromatic Compounds Streamlining Synthesis via C-H Oxidation Byproduct-Free C-C Bond Formation via Catalytic Hydrogenation and Transfer Hydrogenation Enzymo-Metallic Dynamic Kinetic Resolution as a New Tool for Chiral Synthesis Some Progress of Organic Synthesis of Pharmaceuticals in China PART 3: USEFUL SYNTHTIC TECHNOLOGIES Boron Reagents in Process Chemistry: Excellent Tools for Selective Reductions Commercialization of a Sodium Hydride Mediated Arylation Process An Entirely New Methodology for Synthesizing Perfluorinated Compounds Application of Whole-Cell Biocatalysts in the Manufacture of Fine Chemicals PART 4: CONSTRUCTION OF EFFICIENT PRACTICAL PROCESSES Synthetic Studies on the Halichondrin B Analog, Eribulin Mesylate Process Development of An Anthracycline Anticancer Drug Process Development of HIV Integrase Inhibitor S-1360 An Efficient Synthesis of the PKC Inhibitor JTT-010 Practical Process Development of KRP-103 for Treatment of Urinary Incontinence Development of a Novel Synthetic Method for RNA Oligomers PART 5: USEFUL ENGINEERING TECHNOLOGIES Process Research with Explosive Reactions Novel Resolution Technologies Controlled by Effectively Designed Molecular Recognition Mechanism Development on New Drug and Crystal Polymorph Measurements and Mechanism of Drying of Active Pharmaceutical Ingredients Matching Chemistry with Chemical Engineering for Optimum Design and Performance of Pharmaceutical Processing Design Space for Drug Substance - the Approach used for Vandetanib

• ISBN: 978-3-527-32650-1
• Editorial: Wiley-VCH
• Encuadernacion: Cartoné
• Páginas: 526
• Fecha Publicación: 27/10/2010
• Nº Volúmenes: 1
• Idioma: Inglés