Much work over the last two decades has firmly established that loss of cell cycle checkpoint regulation, and resultant unabated cellular proliferation, isan inherent characteristic of cancer. This loss may occur through aberration in any single component involved in signal transduction pathways that orchestrate checkpoint regulation, which may manifest through either a failure to activate the checkpoint or a failure to respond to the activated checkpoint. In normal cells, checkpoint pathways are activated when genetic or cellular homeostasis is compromised, and signals are then transduced to re-stabilize homeostasis, and, failing this, to activate the apoptotic machinery to induce a cellular suicidal response. This implies that both survival and cell death pathways are induced following checkpoint activation, and that the final decision is dependant on the net result of integrating the two sets of signals. Brings together experts, who are defining the field of checkpoints, and as such represents a unique collection of insightful contributions that will serve as an important resource for both the research community and the medical oncologists Since checkpoint regulation is critical in understanding cancer development and cancer therapy, the interest will be diverse and appeal to both basic and translational investigators alike
- ISBN: 978-1-60761-177-6
- Editorial: Humana
- Encuadernacion: Cartoné
- Páginas: 300
- Fecha Publicación: 01/05/2009
- Nº Volúmenes: 1
- Idioma: Inglés