Adapting the heterocyclic core of a single-target molecule can facilitate its development into an agent capable of acting on multiple targets. Such multi-targeting drugs have the potential to become essential components in the design of novel, holistic treatment plans for complex diseases, making the design of such active agents an increasingly important area of research. Key Heterocycle Cores for Designing Multi- targeting Molecules provides a helpful overview of current developments in this field. Following a detailed introduction to the manipulation of heterocycle cores for the development of dual or multi-targeting molecules, the book goes on to describe specific examples of such developments, focusing on compounds including Benzimidazole, Acridine, Flavones, Thiazolidinedione and Oxazoline. Drawing on the latest developments in the field, this volume provides a valuable guide to current approaches in the design and development of molecules capable of acting on multiple targets. Emphasizes the chemical development of heterocyclic nuclei from single to multi-targeting moleculesProvides chapter-by-chapter coverage of the key heterocyclic compounds used in synthesizing multi-targeting agentsOutlines current trends and future developments in multi-target molecule design for the treatment of various important diseases INDICE: 1. Multi-targeting heterocycles an improved and rational chemical probes for multifactorial diseases 2. Benzimidazole: journey from a single targeting to a multitargeting nucleus 3. Acridines: a relatively lesser explored heterocycle for multifactorial diseases 4. Flavones: chemical moiety with vast putative multitargeting potential 5. Thiazolidinedione: potential weapon for targeting multiple pathological condition 6. Oxindole: nucleus possessing variety of therapeutic benefits 7. Thiazines: a versatile heterocyclic scaffold for multifactorial diseases 8. Indoles: An under-recognized heterocycle with vast pharmacological potential 9. Triazoles: multidimensional 5-membered nucleus for designing multitargeting agents 10. Benzoxazolinone: a scaffold with diverse pharmacological significance 11. Benzotriazole: An outlook as multi-targeting agents
- ISBN: 978-0-08-102083-8
- Editorial: Elsevier
- Encuadernacion: Rústica
- Páginas: 410
- Fecha Publicación: 01/04/2018
- Nº Volúmenes: 1
- Idioma: Inglés